Hossam Eid Gewaid
7 Papers
29 Citations
Hossam Eid Gewaid is an academic researcher. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 3, co-authored 3 publications.
Chat about Author
Papers
Current trends in COVID-19 diagnosis and its new variants in physiological fluids: Surface antigens, antibodies, nucleic acids, and RNA sequencing
Menna Mostafa,Ahmed Barhoum,Ekin Sehit,Hossam Eid Gewaid,Eslam S. Mostafa,Mohamed Omran,Mohga S Abdalla,Fatehy M. Abdel-Haleem,Zeynep Altintas,Robert J. Forster +9 more
TL;DR: A comprehensive overview of the current techniques developed for the detection of SARS-CoV-2 in various body fluids (e.g., blood, urine, feces, saliva, tears, and semen) and considers the mutations (i.e., Alpha, Beta, Gamma, Delta, Omicron) is provided in this paper .
23
Schistosoma mansoni soluble egg antigens enhance HCV replication in mammalian cells
Mahmoud M. Bahgat,Mohamed El-Far,Ahmed Atef Mesalam,Amany Abd-Elghany Ismaeil,Ahmed Atef Ibrahim,Hossam Eid Gewaid,Amany Sayed Maghraby,Mohamed A. Ali,Dina Nadeem Abd-Elshafy +8 more
TL;DR: HepG2 cells as well as whole blood cultures maintain HCV replication and SEA has the potential to enhance HCV propagation.
Characterization of NS3 protease from an Egyptian HCV genotype 4a isolate
Mahmoud M. Bahgat,Ahmed Atef Ibrahim,Dina Nadeem Abd-Elshafy,Ahmed Atef Mesalam,Hossam Eid Gewaid,Amany Abd-Elghany Ismaeil,Ahmed M. El-Waseef,Amany Sayed Maghraby,Ahmed Barakat,Mohamed El-Far,Hossam E. Ghanem,Amro Mahmoud Mohamed,Mohamed A. Ali +12 more
TL;DR: Multiple alignments of protease peptides showed that the catalytic triads and binding residues for substrate, Zn2+ and the NS4 cofactor are conserved among different isolates, including the authors', and confirmed the closer homology between NS3 of genotypes 4 and 1.
12
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication
Saravjeet Singh,S. O’Reilly,Hossam Eid Gewaid,Andrew G. Bowie,Virginie Gautier,D. Margaret Worrall +5 more
TL;DR: Modified serpin inhibitors with increased specificity for furin, transmembrane protease serine 2, and cathepsin L were generated and able to inhibit S-pseudoparticle entry into A549-ACE2-TMPRSS2 cells and suppress SARS-CoV-2 replication in Vero E6 cells expressing TMPR SS2.
Regulation of type I and type III interferon induction in response to pathogen sensing.
Hossam Eid Gewaid,Andrew G Bowie +1 more
TL;DR: This review examines the regulation of type I and III interferon induction in response to pathogen sensing, highlighting recent developments on signalling pathways and sensing mechanisms triggered by different pathogens, including SARS-CoV-2.
6