Hongying Yang
Boston College
16 Papers
144 Citations
Hongying Yang is an academic researcher from Boston College. The author has contributed to research in topics: Biology & Sirtuin 1. The author has an hindex of 12, co-authored 15 publications. Previous affiliations of Hongying Yang include Rice University & Harvard University.
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Papers
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne,Philip D. Lambert,Simon Schenk,David P. Carney,J. Joshua Smith,David J. Gagne,Lei Jin,Olivier Boss,Robert B. Perni,Chi B. Vu,Jean Bemis,Roger Xie,Jeremy S. Disch,Pui Yee Ng,Joseph J. Nunes,Amy V. Lynch,Hongying Yang,Heidi Galonek,Kristine Israelian,Wendy Choy,Andre Iffland,Siva Lavu,Oliver Medvedik,David A. Sinclair,Jerrold M. Olefsky,Michael R. Jirousek,Peter J. Elliott,Christoph H. Westphal +27 more
TL;DR: These compounds bind to the SIRT1 enzyme–peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates and improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver.
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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival
Hongying Yang,Tianle Yang,Joseph A. Baur,Evelyn Perez,Takashi Matsui,Juan Carmona,Dudley W. Lamming,Nadja C. de Souza-Pinto,Vilhelm A. Bohr,Anthony Rosenzweig,Rafael de Cabo,Anthony A. Sauve,David A. Sinclair +12 more
TL;DR: Rodents fasted for 48 hr show increased levels of the NAD(+) biosynthetic enzyme Nampt and a concomitant increase in mitochondrial NAD(+) and the relevance of these findings to understanding how nutrition modulates physiology and to the evolution of apoptosis is discussed.
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SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
Hongying Yang,Wei Zhang,Heng Pan,Heidi Galonek Feldser,Elden Lainez,Christine W. Miller,Stewart Leung,Zhong Zhong,Huizhen Zhao,Sharon Sweitzer,Thomas Considine,Thomas V. Riera,Vipin Suri,Brian S. White,James L. Ellis,George P. Vlasuk,Christine Loh +16 more
TL;DR: It is demonstrated that small molecule activators of SIRT1 (STACs) enhance deacetylation of cellular p65 protein, which results in the suppression of TNF α-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT 1-dependent manner.
Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?
TL;DR: It is proposed that there is a functional equivalent of PNC1 in mammals called Nampt (a.k.a. PBEF/Visfatin), a stress-responsive gene that would coordinately regulate metabolism, cell defenses, and resistance to diseases of aging.
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MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase.
TL;DR: Using a combination of functional and structural tools, it is shown that the protein product of the M. jannaschii gene MJ0109, which had been tentatively annotated as an inositol monophosphatase (IMPase), has both IMPase and FBPase activities.
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