Honglan Wang
Ohio State University
22 Papers
320 Citations
Honglan Wang is an academic researcher from Ohio State University. The author has contributed to research in topics: Nitric oxide synthase & Medicine. The author has an hindex of 15, co-authored 17 publications. Previous affiliations of Honglan Wang include China Pharmaceutical University.
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Papers
Nitric Oxide Signaling and the Regulation of Myocardial Function
TL;DR: This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.
149
Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S‐nitrosylation
Honglan Wang,Serge Viatchenko-Karpinski,Junhui Sun,Inna Györke,Nancy A. Benkusky,Mark J. Kohr,Héctor H. Valdivia,Elizabeth Murphy,Sandor Gyorke,Mark T. Ziolo +9 more
TL;DR: NOS1 signalling increases RyR2 activity via S‐nitrosylation, which contributes to the NOS1‐induced positive inotropic effect, which suggests that RyR 2 is an important end target of NOS 1.
92
Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.
Gopal J. Babu,Poornima Bhupathy,Natalia Petrashevskaya,Honglan Wang,Sripriya Raman,Debra G Wheeler,Ganapathy Jagatheesan,David F. Wieczorek,Arnold Schwartz,Paul M.L. Janssen,Mark T. Ziolo,Muthu Periasamy +11 more
TL;DR: It is concluded that SLN is a novel regulator of SERCA pump activity, and its inhibitory effect can be reversed by β-adrenergic agonists.
88
Endothelial nitric oxide synthase decreases β-adrenergic responsiveness via inhibition of the L-type Ca2+ current
TL;DR: Results indicate that NOS3 signaling inhibits the beta-AR response by reducing ICa and protects against arrhythmias, which may play an important role in heart failure.
Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban
Honglan Wang,Mark J. Kohr,Christopher J. Traynham,Debra G Wheeler,Paul M.L. Janssen,Mark T. Ziolo +5 more
TL;DR: NOS1 inhibition or knockout leads to decreased contraction and slowed [Ca2+]i decline, and this effect is absent in PLB-/- myocytes, Thus NOS1 signaling modulates PLB serine16 phosphorylation, in part, via peroxynitrite.