Hongfeng Ruan
Zhejiang University
34 Papers
34 Citations
Hongfeng Ruan is an academic researcher from Zhejiang University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 6 publications.
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Papers
Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth
Yuan-Bo Pan,Ying Gong,Hongfeng Ruan,L Y Pan,Xulu Wu,Chao Tang,Chenggui Wang,Haibin Zhu,Zhikang Zhang,Lanfang Tang,Chaochun Zou,Hao Wang,Ximei Wu +12 more
TL;DR: Results uncover that both Shh/Gli2 and Shh /Gli3 signals are required for proper development of murine placentas and are possibly essential for pregnant maintenance.
Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.
Yuying Chen,Chengcong Zhou,Y. Bian,Fangda Fu,Bian'an Zhu,Xuyan Zhao,MuXin Zhang,Chunyuan Zhou,Sai Yao,Zhiguo Zhang,Huan Luo,Yuying Ge,Chengliang Wu,Hongfeng Ruan +13 more
TL;DR: Wang et al. as mentioned in this paper showed that Cd exposure could reduce body weight and induce thyroid toxicity by impairing thyroid morphology and endocrine function, accompanied by elevated oxidative stress and apoptosis, macrophage infiltration, and inflammatory cytokine secretion.
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Morroniside attenuates nucleus pulposus cell senescence to alleviate intervertebral disc degeneration via inhibiting ROS-Hippo-p53 pathway
Chengcong Zhou,Sai Yao,Fangda Fu,Y. Bian,Zhiguo Zhang,Huihao Zhang,Huan Luo,Yuying Ge,Yuying Chen,W. Ji,Kun Tian,Ming Yue,Hongting Jin,Peijian Tong,Chengliang Wu,Hongfeng Ruan +15 more
TL;DR: It is suggested that morroniside protects against NP cell senescence to alleviate IVDD progression by inhibiting the ROS-Hippo-p53 pathway, providing a potential novel therapeutic approach for IVDD.
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Glioma-associated oncogene-2 is essential for trophoblastic fusion by forming a transcriptional complex with Glial cell missing-a
Chao Tang,Chao Tang,Lanfang Tang,Xiaokai Wu,Wenyi Xiong,Hongfeng Ruan,Musaddique Hussain,Junsong Wu,Chaochun Zou,Ximei Wu +9 more
TL;DR: A so far uncharacterized role of Hedgehog/GLI2 signaling in trophoblastic fusion is uncovered, implicating that Hedgehog signaling, through GLI2, could be required for human placental development and pregnancy maintenance.
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Ascorbic acid uptaken by sodium-dependent vitamin C transporter 2 induces βhCG expression through Sp1 and TFAP2A transcription factors in human choriocarcinoma cells.
Lihua Chen,Haibin Zhu,Yibin Pan,Chao Tang,Mai Watanabe,Hongfeng Ruan,Yongjie Wang,Jirong Wang,Hongyi Yao,Takuma Iguchi,Ximei Wu +10 more
TL;DR: The present study revealed the novel effects of AA on polypeptide hormone, βh CG, production and the potential mechanisms governing AA-induced βhCG expression, suggesting the potentially indispensable roles of AA in placental endocrine and pregnant maintenance.
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