Hong-Wen Deng
Tulane University
269 Papers
949 Citations
Hong-Wen Deng is an academic researcher from Tulane University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 31, co-authored 256 publications. Previous affiliations of Hong-Wen Deng include Shanghai University of Science and Technology & Beijing Jiaotong University.
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Papers
Are bone mineral density loci associated with hip osteoporotic fractures? A validation study on previously reported genome-wide association loci in a Chinese population.
Yan Guo,J.-T. Wang,Hehe Liu,Mingrun Li,Tie-Lin Yang,X.-W. Zhang,Liu Youhong,Q. Tian,Hong-Wen Deng +8 more
TL;DR: It is demonstrated that it is feasible and useful to use hip OF as the direct phenotype to conduct genetic studies, to enhance the understanding of the genetic architecture of osteoporosis.
Comparison of statistical methods for subnetwork detection in the integration of gene expression and protein interaction network.
TL;DR: jActiveModules, PinnacleZ and WMAXC performed well in identifying subnetwork with relative high precision and recall, and BioNet performed very well only in precision.
Enhanced Identification of Potential Pleiotropic Genetic Variants for Bone Mineral Density and Breast Cancer.
Cheng Peng,Hui-Ling Lou,Feng Liu,Jie Shen,Xu Lin,Chun-Ping Zeng,Jirong Long,Kuan-Jui Su,Lan Zhang,Jonathan Greenbaum,Wei-Feng Deng,Yu-Mei Li,Hong-Wen Deng,Hong-Wen Deng +13 more
TL;DR: This study highlighted the significant pleiotropic enrichment between BMD and BC and shed novel insight into trait-specific as well as the potentially shared genetic architecture for both B MD and BC.
Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
Yan Guo,Li Jun Tan,Shu Feng Lei,Tie-Lin Yang,Xiang Ding Chen,Feng Zhang,Yuan Chen,Feng Pan,Han Yan,Xiao-Gang Liu,Qing Tian,Zhi Xin Zhang,Qi Zhou,Chuan Qiu,Shan-Shan Dong,Xiang Hong Xu,Yan-Fang Guo,Xue Zhen Zhu,Shan Lin Liu,Xiang Li Wang,Xi Li,Yi Luo,Li Shu Zhang,Meng Li,Jin Tang Wang,Ting Wen,Betty M. Drees,James A. Hamilton,Christopher J. Papasian,Robert R. Recker,Xiaoping Song,Jing Cheng,Hong-Wen Deng +32 more
TL;DR: A SNP, rs13182402 within the ALDH7A1 gene on chromosome 5q31, was strongly associated with OF with evidence combined GWAS and replication studies, and was confirmed as consistently associated with hip BMD even across ethnic boundaries, in both Chinese and Caucasians.
A new permutation strategy of pathway-based approach for genome-wide association study.
TL;DR: The findings indicate the improved performance of SNP permutation will render pathway-based analysis of GWAS more applicable and attractive and thus render the proposed permutation strategy more powerful and efficient.