Hong-Wen Deng
Tulane University
269 Papers
949 Citations
Hong-Wen Deng is an academic researcher from Tulane University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 31, co-authored 256 publications. Previous affiliations of Hong-Wen Deng include Shanghai University of Science and Technology & Beijing Jiaotong University.
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Papers
Detection of copy number variation from next generation sequencing data with total variation penalized least square optimization
Junbo Duan,Ji-Gang Zhang,John Lefante,Hong-Wen Deng,Yu-Ping Wang +4 more
- 12 Nov 2011
TL;DR: Inspired by the analytical study of a statics system, an iterative algorithm is proposed to find the optimal solution of this optimization problem to detect copy number variation from next generation sequencing data.
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Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese
Feng Zhang,Yan Wen,Xiong Guo,Yin-gang Zhang,Sen Wang,Tie-Lin Yang,Hui Shen,Xiang-Ding Chen,Li-Jun Tan,Qing Tian,Hong-Wen Deng +10 more
TL;DR: This study is the first to suggest that complement system-related CACC pathway contributed to the development of KBD.
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Mass spectrometry based proteomics profiling of human monocytes
Yong Zeng,Yong Zeng,Fei-Yan Deng,Fei-Yan Deng,Wei Zhu,Wei Zhu,Lan Zhang,Hao He,Chao Xu,Qing Tian,Ji-Gang Zhang,Li-Shu Zhang,Honggang Hu,Hong-Wen Deng,Hong-Wen Deng +14 more
TL;DR: This study developed the first comprehensive proteome knowledge base specifically for human monocytes by integrating both in vivo and in vitro datasets, and revealed a number of genes such as SAMHD1, G6PD, GPD2 and ENO1 which have been reported to be related to immune response, blood biology, bone remodeling, and cancer respectively.
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Estimates of the effects of physical activity on osteoporosis using multivariable Mendelian randomization analysis.
TL;DR: In this article, a multivariable Mendelian randomization (MR) was used to estimate the causal effect of physical activity on bone mineral density (BMD) in individuals.
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Bivariate genome-wide association analyses identified genetic pleiotropic effects for bone mineral density and alcohol drinking in Caucasians.
Shan Lu,Lan-Juan Zhao,Xiang-Ding Chen,Christopher J. Papasian,Ke-Hao Wu,Li-Jun Tan,Zhuo-Er Wang,Yu-Fang Pei,Qing Tian,Hong-Wen Deng,Hong-Wen Deng,Hong-Wen Deng +11 more
TL;DR: The study indicated that DYNC2H1 may contribute to the genetic mechanisms of both spine BMD and alcohol drinking in male Caucasians, and suggested potential pleiotropic roles of OPRM1 and IL1RN in females and GRIK4 in males underlying variation of both BMDand alcohol drinking.
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