Hong-Wen Deng
Tulane University
269 Papers
949 Citations
Hong-Wen Deng is an academic researcher from Tulane University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 31, co-authored 256 publications. Previous affiliations of Hong-Wen Deng include Shanghai University of Science and Technology & Beijing Jiaotong University.
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Papers
Effect of polygenes on Xiong's transmission disequilibrium test of a QTL in nuclear families with multiple children.
TL;DR: The results of this study should be of theoretical significance in generalizing the investigation of the TDT to biologically plausible situations with background polygenes and should also be of practical values in providing guidance on the recruitment of nuclear families with multiple children with the TDTG.
Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis
Y. Zeng,Lei Zhang,Wei Zhu,Wei Zhu,Hao He,H. Sheng,Qing Tian,Fei-Yan Deng,Fei-Yan Deng,Li-Shu Zhang,Honggang Hu,Hong-Wen Deng,Hong-Wen Deng +12 more
TL;DR: This study strongly supports the significance of the genes P4HB, ITGB1, CD36, and ACTN1 to the etiology of osteoporosis risk.
Critical assessment of coalescent simulators in modeling recombination hotspots in genomic sequences
TL;DR: MaCS and fastsimcoal are much more scalable and flexible in simulating a variety of demographic events under different recombination hotspot models, and appear to give the most optimal performance in detecting and validating cross-over hotspots.
Integrative analysis of genome-wide association studies and gene expression profiles identified candidate genes for osteoporosis in Kashin-Beck disease patients
Yan Wen,Xiong Guo,Jingcan Hao,Xiao Xiao,Wenyu Wang,Cuiyan Wu,Sen Wang,Tie-Lin Yang,Hui Shen,Xiang-Ding Chen,Li-Jun Tan,Qing Tian,Hong-Wen Deng,Feng Zhang +13 more
TL;DR: It is suggested that Kashin-Beck disease and OP shared some common causal genes, functionally involved in skeletal growth and development and chronic inflammation, and several candidate genes involved in the development of OP in KBD patients are reported.
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Gene Expression and RNA Splicing Imputation Identifies Novel Candidate Genes Associated with Osteoporosis
Yong Liu,Yong Liu,Hui Shen,Jonathan Greenbaum,Anqi Liu,Kuan-Jui Su,Li-Shu Zhang,Lei Zhang,Qing Tian,Honggang Hu,Jin-Sheng He,Hong-Wen Deng,Hong-Wen Deng +12 more
TL;DR: The findings provide novel insights into the pathogenesis mechanisms of osteoporosis and highlight the power of TWAS to identify and prioritize potential causal genes.
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