Hong-Wen Deng
Tulane University
269 Papers
949 Citations
Hong-Wen Deng is an academic researcher from Tulane University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 31, co-authored 256 publications. Previous affiliations of Hong-Wen Deng include Shanghai University of Science and Technology & Beijing Jiaotong University.
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Papers
Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics
Dan-Yang Liu,Jia-Chen Liu,Shuang Liang,Xiang-He Meng,Jonathan Greenbaum,Hong-Mei Xiao,Li-Jun Tan,Hong-Wen Deng,Hong-Wen Deng,Hong-Wen Deng +9 more
TL;DR: In this article, the authors used an integrated network-based pharmacologic and transcriptomic approach to screen drug candidates for COVID-19 treatment, and 30 synergistic drug pairs were ultimately recommended including fostamatinib plus tretinoin and orantinib plus valproic acid.
20
Systemic analysis of osteoblast-specific DNA methylation marks reveals novel epigenetic basis of osteoblast differentiation.
TL;DR: The integrated evidences from DMR analysis, histone modification and RNA-seq data strongly support that there is a novel isoform of neurexin-2 (NRXN2) gene specifically expressed in osteoblast, suggesting diverse DNA methylation-mediated regulatory mechanisms.
20
Genome-Wide Pathway Association Studies of Multiple Correlated Quantitative Phenotypes Using Principle Component Analyses
TL;DR: Simulations using the real data from the HapMap project were conducted to evaluate the power and type I error rates of PCA-based MPPAS under various scenarios considering sample sizes, additive and interactive genetic effects.
Genome-wide Association Study of Exercise Behavior in Dutch
HM De Moor,Yong Jun Liu,Dorret I. Boomsma,Jian Li,James J. Hamilton,Jouke-Jan Hottenga,Shawn Levy,Xiaogang Liu,Yu-Fang Pei,Danielle Posthuma,Robert R. Recker,Patrick F. Sullivan,Liang Wang,Gonneke Willemsen,Han Yan,Hong-Wen Deng +15 more
- 01 Jan 2011
TL;DR: This study identified genetic variants that are associated with adult leisure-time exercise behavior using genome-wide association in two independent samples using regression-based techniques in SNPtest, including sex, age and BMI as covariates.
20
Bivariate Genome-Wide Association Analyses Identified Genes with Pleiotropic Effects for Femoral Neck Bone Geometry and Age at Menarche
Shu Ran,Yu-Fang Pei,Yong-Jun Liu,Lei Zhang,Yingying Han,Rong Hai,Qing Tian,Yong Lin,Tie-Lin Yang,Yan-Fang Guo,Hui Shen,Inderpal S. Thethi,Xue-Zhen Zhu,Hong-Wen Deng,Hong-Wen Deng +14 more
TL;DR: Six SNPs are found located in three genes (i.e. NRCAM, IDS and LOC148145), suggesting these three genes may co-regulate FNGPs and AAM, and may help improve the understanding of genetic architecture and pathophysiological mechanisms underlying both osteoporosis and A AM.