Hong Shi
Case Western Reserve University
23 Papers
121 Citations
Hong Shi is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Medicine & Endothelium. The author has an hindex of 13, co-authored 17 publications. Previous affiliations of Hong Shi include Mount Vernon Hospital & Huazhong University of Science and Technology.
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Papers
Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice
Guangjin Zhou,Anne Hamik,Lalitha Nayak,Hongmei Tian,Hong Shi,Yuan Lu,Nikunj Sharma,Xudong Liao,Andrew T. Hale,Lauren M Boerboom,Ryan E. Feaver,Huiyun Gao,Amar Desai,Alvin H. Schmaier,Stanton L. Gerson,Yunmei Wang,G. Brandon Atkins,Brett R. Blackman,Daniel I. Simon,Mukesh K. Jain +19 more
TL;DR: It is shown that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis andMechanistically, it is demonstrated that KLF 4 differentially regulated pertinent endothelial targets via competition for the coactivator p300, and cogent evidence is provided implicated as essential in vivo regulators of vascular function in the adult animal.
The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
Ganapati H. Mahabeleshwar,Daiji Kawanami,Nikunj Sharma,Yoichi Takami,Guangjin Zhou,Hong Shi,Lalitha Nayak,Darwin Jeyaraj,Robert Grealy,Mary C. White,Ross McManus,Thomas J. Ryan,Patrick Leahy,Zhiyong Lin,Saptarsi M. Haldar,G. Brandon Atkins,Hector R. Wong,Jerry B. Lingrel,Mukesh K. Jain +18 more
TL;DR: In this paper, the authors identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo, and demonstrate that exposure to either hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxyia inducible factor 1α (HIF-1α), findings that were recapitulated in human septic patients.
137
Kruppel-like Factor 2 Protects Against Ischemic Stroke by Regulating Endothelial Blood Brain Barrier Function
Hong Shi,Baiyang Sheng,Feng Zhang,Chunying Wu,Rongli Zhang,Junqing Zhu,Kui Xu,Youzhi Kuang,Stephen C. Jameson,Zhiyong Lin,Yanming Wang,Jun Chen,Mukesh K. Jain,G. Brandon Atkins +13 more
TL;DR: Mechanistically, KLF2 was demonstrated, both in vitro and in vivo, to regulate the critical BBB tight junction factor occludin and is identified as a key regulator of the BBB and a novel neuroprotective factor in ischemic stroke.
85
Circadian control of bile acid synthesis by a KLF15-Fgf15 axis
Shuxin Han,Rongli Zhang,Rajan Jain,Hong Shi,Lilei Zhang,Guangjin Zhou,Panjamaporn Sangwung,Derin Tugal,G. Brandon Atkins,Domenick A. Prosdocimo,Yuan Lu,Xiaonan Han,Patrick Tso,Xudong Liao,Jonathan A. Epstein,Mukesh K. Jain +15 more
TL;DR: In this paper, the authors identify a KLF15-Fgf15 signalling axis that regulates BA production in the liver and find that it is a potent inhibitor of BA synthesis.
Corrigendum: Circadian control of bile acid synthesis by a KLF15-Fgf15 axis.
Shuxin Han,Rongli Zhang,Rajan Jain,Hong Shi,Lilei Zhang,Guangjin Zhou,Panjamaporn Sangwung,Derin Tugal,G. Brandon Atkins,Domenick A. Prosdocimo,Yuan Lu,Xiaonan Han,Patrick Tso,Xudong Liao,Jonathan A. Epstein,Mukesh K. Jain +15 more
TL;DR: The author Shuxin Han’s aim is to provide a simple, scalable, scalable and scalable instrument that can be integrated into the manufacturing process and provide real-time information about the response of the immune system to EMT.