Hong Li
Genentech
5 Papers
Hong Li is an academic researcher from Genentech. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 3 publications.
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Papers
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
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Transcription factor Etv5 is essential for the maintenance of alveolar type II cells
Zhen Zhang,Kim Newton,Sarah K. Kummerfeld,Joshua D. Webster,Donald S. Kirkpatrick,Lilian Phu,Jeffrey Eastham-Anderson,Jinfeng Liu,Wyne P. Lee,Jiansheng Wu,Hong Li,Melissa R. Junttila,Vishva M. Dixit +12 more
TL;DR: It is shown that a critical output of Ras signaling in AT2 cells is inactivation of the ubiquitin ligase COP1, resulting in stabilization of the transcription factor ETV5, which is essential to maintain AT2 cell identity.
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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis
Joseph Chavarría-Smith,Cecilia Chiu,Janet Jackman,Jianping Yin,Jun Zhang,Jason A. Hackney,Wei Lin,Tulika Tyagi,Yonglian Sun,Janet Tao,Debra Y. Dunlap,William D. Morton,Swapnil V. Ghodge,Henry R. Maun,Hong Li,Hilda Hernandez-Barry,Kelly M. Loyet,Emily I. Chen,John Liu,Christine Tam,Brian L. Yaspan,Hao Cai,Mercedesz Balazs,Joseph R. Arron,Jing Li,Arthur J. Wittwer,Rajita Pappu,Cary D. Austin,Wyne P. Lee,Robert A. Lazarus,Jawahar Sudhamsu,James T. Koerber,Tangsheng Yi +32 more
TL;DR: Chavarria-Smith et al. as mentioned in this paper developed a bispecific inhibitory antibody against KLK5 and KLK7 for treatment of Netherton Syndrome and atopic dermatitis.
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Corrigendum to "A novel method to produce synthetic murine CXCL10 for efficient screening of functional variants" [Bioorg. Chem. 116 (2021) 105376].
Jérémie Decalf,Jeffrey Tom,Elaine Mai,Hilda Hernandez-Barry,Cameron L. Noland,Breanna S. Vollmar,Anhu Li,Hong Li,Daniel Xie,Lunchao Zhu,Jian Payandeh,Kelly M. Loyet,Cong Wu,Laetitia Comps-Agrar,Christine Moussion,Matthew L. Albert,Aimin Song +16 more
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
Christine Pozniak,Arundhati Sengupta Ghosh,Alvin Gogineni,Jesse E. Hanson,Seung-Hye Lee,Jessica L. Larson,Hilda Solanoy,Daisy Bustos,Hong Li,Hai Ngu,Adrian M. Jubb,Gai Ayalon,Jiansheng Wu,Kimberly Scearce-Levie,Qiang Zhou,Robby M. Weimer,Donald S. Kirkpatrick,Joseph W. Lewcock +17 more
TL;DR: Loss of dual leucine zipper kinase results in attenuated JNK/c-Jun stress response pathway activation and reduced neuronal degeneration after kainic acid–induced excitotoxic seizures.