Holly Steininger
Stanford University
12 Papers
Holly Steininger is an academic researcher from Stanford University. The author has contributed to research in topics: Stem cell & Medicine. The author has an hindex of 3, co-authored 5 publications.
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Papers
Articular cartilage regeneration by activated skeletal stem cells.
Matthew P. Murphy,Matthew P. Murphy,Lauren S. Koepke,Michael T. Lopez,Xinming Tong,Thomas H. Ambrosi,Gunsagar S. Gulati,Owen Marecic,Yuting Wang,Yuting Wang,Ryan C. Ransom,Malachia Y. Hoover,Holly Steininger,Liming Zhao,Liming Zhao,Marcin P. Walkiewicz,Natalina Quarto,Benjamin Levi,Derrick C. Wan,Irving L. Weissman,Stuart B. Goodman,Fan Yang,Michael T. Longaker,Charles Chan +23 more
TL;DR: Endogenous skeletal stem cells are recruited to form cartilage in mice when stimulated by microfracture surgery together with localized delivery of growth factors, pointing to a new approach for treating cartilage defects.
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Aged skeletal stem cells generate an inflammatory degenerative niche.
Thomas H. Ambrosi,Owen Marecic,Adrian McArdle,Rahul Sinha,Gunsagar S. Gulati,Xinming Tong,Yuting Wang,Holly Steininger,Malachia Y. Hoover,Lauren S. Koepke,Matthew P. Murphy,Jan Sokol,Eun Young Seo,Ruth Tevlin,Michael Lopez,Rachel E. Brewer,Shamik Mascharak,Laura Lu,Oyinkansola Ajanaku,Stephanie D. Conley,Jun Seita,Maurizio Morri,Norma Neff,Debashis Sahoo,Fan Yang,Irving L. Weissman,Michael T. Longaker,Charles Chan +27 more
TL;DR: This paper showed that intrinsic ageing of SSCs in mice alters signalling in the bone marrow niche and skews the differentiation of bone and blood lineages, leading to fragile bones that regenerate poorly.
236
Distinct skeletal stem cell types orchestrate long bone skeletogenesis.
Thomas H. Ambrosi,Rahul Sinha,Holly Steininger,Malachia Y. Hoover,Matthew P. Murphy,Lauren S. Koepke,Yuting Wang,Wan Jin Lu,Maurizio Morri,Norma Neff,Irving L. Weissman,Michael T. Longaker,Charles Chan +12 more
TL;DR: This paper showed that postnatal long bones of mice contain at least two types of bone progenitors with bona fide skeletal stem cell (SSC) characteristics, i.e., early osteochondral SSC (ocSSC), which facilitates long bone growth and repair, and perivascular SSC, which contributes to shape the hematopoietic stem cell niche and regenerative demand.
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Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration
Tom W. Andrew,Lauren S. Koepke,Yuting Wang,Michael Lopez,Holly Steininger,D. Struck,Tatiana Boyko,Thomas H. Ambrosi,Xinming Tong,Yuxi Sun,Gunsagar S. Gulati,Matthew P. Murphy,Owen Marecic,Ruth Telvin,Katharina Schallmoser,Dirk Strunk,Jun Seita,Stuart B. Goodman,Fan Yang,Michael T. Longaker,George P. Yang,Charles Chan +21 more
TL;DR: In this article , the skeletal stem cell (SSC) mediated regeneration in female mice is dependent on estrogen signaling but SSCs from male mice do not exhibit similar estrogen responsiveness.
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Purification and functional characterization of novel human skeletal stem cell lineages
Malachia Hoover,Thomas H. Ambrosi,Holly Steininger,Lauren S. Koepke,Yuting Wang,Liming Zhao,Matthew P. Murphy,Elizabeth Arouge,E. Takematsu,Serena S. Hu,Debashis Sahoo,Rahul Sinha,Maurizio Morri,Norma F. Neff,Julius A. Bishop,Michael J. Gardner,Stuart B. Goodman,Michael T. Longaker,Charles Chan +18 more
TL;DR: An advanced flow cytometric approach that utilizes an extensive panel of eight cell surface markers to define hSSCs; bone, cartilage and stromal progenitors; and more differentiated unipotent subtypes, including an osteogenic subset and three chondroprogenitors is described.
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