Holly Stefen
Macquarie University
8 Papers
20 Citations
Holly Stefen is an academic researcher from Macquarie University. The author has contributed to research in topics: Actin cytoskeleton & Growth cone. The author has an hindex of 4, co-authored 8 publications. Previous affiliations of Holly Stefen include University of New South Wales.
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Papers
Tropomyosin Tpm3.1 is required to maintain the structure and function of the axon initial segment
Amr Abouelezz,Amr Abouelezz,Holly Stefen,Mikael Segerstråle,David Micinski,Rimante Minkeviciene,Edna C. Hardeman,Peter W. Gunning,Casper C. Hoogenraad,Tomi Taira,Thomas Fath,Pirta Hotulainen +11 more
TL;DR: This study found that the tropomyosin isoform Tpm3.1 decorates a population of relatively stable actin filaments in the AIS which provides a scaffold for membrane organization and AIS proteins.
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Syntaxins 6 and 8 facilitate tau into secretory pathways.
Wei Siang Lee,Daniel C. S. Tan,Yuanyuan Deng,Annika van Hummel,Stefania Ippati,Claire Stevens,Paulina Carmona-Mora,Daryl Ariawan,Liming Hou,Holly Stefen,Tamara Tomanic,Mian Bi,Florence Tomasetig,Adam D. Martin,Thomas Fath,Stephen J. Palmer,Yazi D. Ke,Lars M. Ittner +17 more
TL;DR: In this paper, the authors established the interactome of the C-terminal tail region of tau and identified syntaxin 8 (STX8) as a mediator of Tau release from cells.
Deletion of the Actin-Associated Tropomyosin Tpm3 Leads to Reduced Cell Complexity in Cultured Hippocampal Neurons-New Insights into the Role of the C-Terminal Region of Tpm3.1.
TL;DR: In this article, the effect of truncation on the ability of Tpm31 to modulate neuronal morphogenesis was investigated in primary mouse hippocampal neurons of C57/Bl6 wild type and Bl6Tpm3flox transgenic mice.
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Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice.
Merryn Brettle,Holly Stefen,Aleksandra Djordjevic,Sandra Fok,Josephine W. Chan,Annika van Hummel,Julia van der Hoven,Magdalena Przybyla,Alexander Volkerling,Yazi D. Ke,Fabien Delerue,Lars M. Ittner,Thomas Fath,Thomas Fath +13 more
TL;DR: Although profilin 1 C71G was only expressed during development, adult mice presented with some ALS-associated pathology and motor symptoms, and the impact that this may have in later ALS is highlighted.
Overexpression of Tropomyosin Isoform Tpm3.1 Does Not Alter Synaptic Function in Hippocampal Neurons
Chanchanok Chaichim,Chanchanok Chaichim,Tamara Tomanic,Holly Stefen,Esmeralda Paric,Lucy Gamaroff,Alexandra K Suchowerska,Peter W. Gunning,Yazi D. Ke,Thomas Fath,John M. Power +10 more
TL;DR: In this article, the authors studied the role of Tpm3.1 in the formation and function of dendritic spines in cultured hippocampal neurons from transgenic mice overexpressing it.