Holger Webert
University of Marburg
6 Papers
Holger Webert is an academic researcher from University of Marburg. The author has contributed to research in topics: Ferredoxin & Biology. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Holger Webert include Max Planck Society.
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Papers
Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis.
Alex D. Sheftel,Oliver Stehling,Antonio J. Pierik,Hans-Peter Elsässer,Ulrich Mühlenhoff,Holger Webert,Anna Hobler,Frank Hannemann,Rita Bernhardt,Roland Lill +9 more
TL;DR: It is concluded that mammals depend on two distinct mitochondrial ferredoxins for the specific production of either steroid hormones or heme A and Fe/S proteins.
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Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin
Holger Webert,Sven-Andreas Freibert,Angelo Gallo,Torsten Heidenreich,Uwe Linne,Stefan Amlacher,Ed Hurt,Ulrich Mühlenhoff,Lucia Banci,Roland Lill +9 more
TL;DR: The molecular function of the ferredoxin Yah1 and its human orthologue FDX2 in mitochondrial Fe/S cluster synthesis is defined and a pathway for electron flow from reduced ferred toxin to Isu1 is suggested.
Coenzyme Q Biosynthesis: Coq6 Is Required for the C5-Hydroxylation Reaction and Substrate Analogs Rescue Coq6 Deficiency
Mohammad Ozeir,Ulrich Mühlenhoff,Holger Webert,Roland Lill,Marc Fontecave,Fabien Pierrel,Fabien Pierrel +6 more
TL;DR: It is established here that Coq6, a predicted flavin-dependent monooxygenase, is involved exclusively in the C5-hydroxylation reaction, and appropriate analogs of 4-hydroxybenzoic acid can bypass a deficient Q biosynthetic enzyme.
110
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2
Vinzent Schulz,Somsuvro Basu,Sven-Andreas Freibert,Holger Webert,Linda Boss,Ulrich Mühlenhoff,Fabien Pierrel,Lars-Oliver Essen,Douglas M. Warui,Squire J. Booker,Oliver Stehling,Roland Lill +11 more
TL;DR: In this paper , the authors identify new biochemical tasks of mitochondrial ferredoxins and provide structural insights into their functional specificity, and identify lipoylation as a target of the toxic antitumor copper ionophore elesclomol.
The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism ☆
Roland Lill,Bastian Hoffmann,Sabine Molik,Antonio J. Pierik,Nicole Rietzschel,Oliver Stehling,Marta A. Uzarska,Holger Webert,Claudia Wilbrecht,Ulrich Mühlenhoff +9 more
TL;DR: Fe/S protein biogenesis and cellular iron metabolism are tightly linked to coordinate iron supply and utilization.