Hoa Le
Genentech
17 Papers
35 Citations
Hoa Le is an academic researcher from Genentech. The author has contributed to research in topics: Chemistry & Pharmacokinetics. The author has an hindex of 9, co-authored 16 publications.
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Papers
Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
Lichuan Liu,Jason Halladay,Young G. Shin,Susan Wong,Melis Coraggio,Hank La,Matthew Baumgardner,Hoa Le,Sashi Gopaul,Jason Boggs,Peter Kuebler,John C. Davis,X. Charlene Liao,Joseph W. Lubach,Alan Deese,C. Gregory Sowell,Kevin S. Currie,Wendy B. Young,S. Cyrus Khojasteh,Cornelis E. C. A. Hop,Harvey Wong +20 more
TL;DR: Uncertainty in human pharmacokinetic prediction and high interest in a BTK inhibitor for clinical evaluation prompted an investigational new drug strategy, in which GDC-0834 was rapidly advanced to a single-dose human clinical trial.
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Comparison of Metabolic Soft Spot Predictions of CYP3A4, CYP2C9 and CYP2D6 Substrates Using MetaSite and StarDrop
TL;DR: Overall the software were comparable except for MetaSite performing better for CYP2D6 and that MetaSite has a liver model that is absent in StarDrop that predicted with 82% accuracy.
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Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads
Donglu Zhang,Hoa Le,Josefa dela Cruz-Chuh,Sudheer Bobba,Jun Guo,Leanna Staben,Chenghong Zhang,Yong Ma,Katherine R. Kozak,Gail Lewis Phillips,Breanna S. Vollmar,Jack Sadowsky,Richard Vandlen,Binqing Wei,Dian Su,Peter W. Fan,Peter S. Dragovich,S. Cyrus Khojasteh,Cornelis E. C. A. Hop,Thomas H. Pillow +19 more
TL;DR: T careful evaluation needs to be conducted when the Val-Cit-PAB linker is used to connect antibodies to a phenol-containing drug as the linker immolation, as well as payload potency and stability, affects the cell-killing activity of an ADC.
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Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions.
Susan Wong,Utkarsh Doshi,Peter Vuong,Ning Liu,Suzanne Tay,Hoa Le,Mika Kosaka,Jane R. Kenny,Albert P. Li,Zhengyin Yan +9 more
TL;DR: It was found that, for CYP3A4/5 substrates such as midazolam, amprenavir and loperamide, in vitro metabolic clearance is generally lower in enterocytes compared to that of hepatocytes, which is consistent with the relative abundance of the enzyme between the intestine and liver.
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Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.
Chenghong Zhang,Jane R. Kenny,Hoa Le,Alan Deese,Kevin A. Ford,Luke Koenigs Lightning,Peter W. Fan,James P. Driscoll,Jason Halladay,Cornelis E. C. A. Hop,S. Cyrus Khojasteh +10 more
TL;DR: A proposed mechanism for dehalogenation and glutathione (GSH) conjugation of a series of ortho-, meta-, and para-dihalogenated anilines observed in human liver microsomes is reported on.
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