Hitoshi Watanabe
Dainippon Sumitomo Pharma Co., Ltd.
9 Papers
56 Citations
Hitoshi Watanabe is an academic researcher from Dainippon Sumitomo Pharma Co., Ltd.. The author has contributed to research in topics: Bicyclic molecule & QT interval. The author has an hindex of 5, co-authored 9 publications.
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Papers
CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability-
Yumiko Nozaki,Yayoi Honda,Hitoshi Watanabe,Shota Saiki,Kiyotaka Koyabu,Tetsuji Itoh,Chiho Nagasawa,Chiaki Nakamori,Chiaki Nakayama,Hiroshi Iwasaki,Shinobu Suzuki,Ikumi Washio,Etsushi Takahashi,Kaori Miyamoto,Atsuhiro Yamanishi,Hiroko Endo,Junko Shinozaki,Hisashi Nogawa,Takeshi Kunimatsu +18 more
TL;DR: The new assay model reported here would enable accurate prediction of a drug potential for proarrhythmia in a multi-electrode array system used for in-vitro screening of hERG channels.
33
Patent
Novel bicyclic heterocyclic compound
Katsunori Tsuboi,Yusuke Yamai,Hitoshi Watanabe,Hironori Kinoshita +3 more
- 25 Dec 2009
TL;DR: In this article, a compound for the treatment or prophylaxis of pathology involving SNS, specifically diseases such as neuropathic pain, nociceptive pain, dysuria, multiple sclerosis and the like, is described.
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Usefulness of cardiotoxicity assessment using calcium transient in human induced pluripotent stem cell-derived cardiomyocytes.
TL;DR: In this paper, the authors examined changes in calcium transient waveforms induced by a series of 17 compounds that include positive/negative inotropic agents as well as cardiac ion channel activators/inhibitors.
25
Patent
Bicyclic heterocyclic compound
Katsunori Tsuboi,Yusuke Yamai,Hitoshi Watanabe,Hironori Kinoshita +3 more
- 25 Dec 2009
TL;DR: In this paper, a compound for the treatment or prophylaxis of pathology involving SNS, specifically diseases such as neuropathic pain, nociceptive pain, dysuria, multiple sclerosis and the like, is described.
2
CSAHi study: Usability assessment of multi-electrode array in combination with human iPS cell-derived cardiomyocytes for prediction of drug-induced QT prolongation and arrhythmia — Multi Channel Systems (MEA60 and MEA2100)
Takeshi Kunimatsu,Yumiko Nozaki,Yayoi Honda,Hitoshi Watanabe,Atsuhiro Yamanishi,Hisashi Nogawa,Hiroko Endo,Shota Saiki,Chiho Nagasawa,Chiaki Nakamori,Chiaki Nakayama,Hiroshi Iwasaki,Etsushi Takahashi,Kaori Miyamoto,Kaoru Morimura,Kohji Tanaka,Shinobu Suzuki,Ikumi Washio +17 more
1