Hisanori Horiuchi
Tohoku University
124 Papers
1.1K Citations
Hisanori Horiuchi is an academic researcher from Tohoku University. The author has contributed to research in topics: GTPase & Medicine. The author has an hindex of 42, co-authored 117 publications. Previous affiliations of Hisanori Horiuchi include Kyoto University & Nihon Pharmaceutical University.
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Papers
Seven-transmembrane receptors
Abstract: 生体内では,ホルモンをはじめとして,多くの生 理活性因子が 7回膜貫通型受容体を介して細胞内に シグナルを伝える.血小板では,トロンビン,トロン ボキサン A2,プロスタサイクリン,platelet activating factor (PAF),ADP,カテコラミン,セロトニン 等多くの分子が 7回膜貫通型受容体を介してシグナ ルを伝える.7回膜貫通型受容体は直接の下流情報 因子として 3量体 GTP結合蛋白質(G蛋白質)を用い るので,G-protein-coupled receptor,GPCRと呼ばれ る.3量体 G蛋白質の種類によって伝わる細胞内情 報が異なる.現在用いられている抗血小板薬は,7 回膜貫通型受容体-3量体 G蛋白質経路のどこかを 制御するものが多い(図 1).本総説では,まず 7回 膜貫通型受容体と 3量体 G蛋白質について説明し, 代表的な血小板上の 7回膜貫通型受容体について概 説する.
661
A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function
Hisanori Horiuchi,Roger Lippé,Heidi M. McBride,Mariantonietta Rubino,Philip G. Woodman,Harald Stenmark,Vladimir Rybin,Matthias Wilm,Keith Ashman,Matthias Mann,Marino Zerial +10 more
TL;DR: It is shown that a soluble exchange factor coupled to a Rab effector translocates from cytosol to the membrane, where the complex stabilizes the GTPase in the active state, as well as a novel 60 kDa Rab5-binding protein, Rabex-5, which is essential for endocytic membrane fusion.
614
Nationwide survey of hemophagocytic lymphohistiocytosis in Japan.
Eiichi Ishii,Shouichi Ohga,Shinsaku Imashuku,Masaki Yasukawa,Hiroyuki Tsuda,Ikuo Miura,Ken Yamamoto,Hisanori Horiuchi,Kenzo Takada,Koichi Ohshima,Shigeo Nakamura,Naoko Kinukawa,Kazuo Oshimi,Keisei Kawa +13 more
TL;DR: Although this nationwide survey establishes the heterogeneous characteristics of HLH, the results should be useful in planning prospective studies to identify the most effective therapy for each HLH subtype.
448
Role of oxidized LDL in atherosclerosis.
Toru Kita,Noriaki Kume,Manabu Minami,Kazutaka Hayashida,Toshinori Murayama,Hideto Sano,Hideaki Moriwaki,Hiroshi Kataoka,Eiichiro Nishi,Hisanori Horiuchi,Hidenori Arai,Masayuki Yokode +11 more
TL;DR: The significance of oxidized LDL and its receptors, LOX‐1 and SR‐PSOX, in terms of atherogenesis is discussed.
257
Munc13-4 Is a GTP-Rab27-binding Protein Regulating Dense Core Granule Secretion in Platelets
Ryutaro Shirakawa,Tomohito Higashi,Arata Tabuchi,Akira Yoshioka,Hiroaki Nishioka,Mitsunori Fukuda,Toru Kita,Hisanori Horiuchi +7 more
TL;DR: Rabo27 regulates the dense core granule secretion in platelets by employing its binding protein, Munc13-4, which mediates the function of GTP-Rab27.
228