Hiroyuki Nakamura
Tokyo Institute of Technology
543 Papers
3.6K Citations
Hiroyuki Nakamura is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Chemistry & Catalysis. The author has an hindex of 52, co-authored 491 publications. Previous affiliations of Hiroyuki Nakamura include Japanese Foundation for Cancer Research & University of Tokyo.
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Papers
Photochemical Conversion of Isoxazoles to 5-Hydroxyimidazolines.
TL;DR: 5-Hydroxyimidazolines were converted into multisubstituted imidazoles in one step by treatment with trifluoroacetic anhydride and 2,6-lutidine in dichloromethane.
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Synthesis of Three-Dimensional (Di)Azatricyclododecene Scaffold and Its Application to Peptidomimetics
Kohei Umedera,Taiki Morita,Atsushi Yoshimori,Kentaro Yamada,Kentaro Yamada,Akira Katoh,Hiroyuki Kouji,Hiroyuki Nakamura +7 more
TL;DR: In this article, a bridged tricyclic 3D scaffold for peptide mimetic compound library was constructed to target protein-protein interactions, which enables the introduction of substituents into the scaffold to mimic amino acid side chains.
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Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity
TL;DR: In this paper, diaryl-substituted carboranes, as a new class of HIF-1α inhibitors, were synthesized from the corresponding diarylsubstitized alkynes by decaborane coupling.
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Microfluidic thermodynamics of the shift in thermal stability of DNA duplex in a microchannel laminar flow.
TL;DR: Details of the shift in thermal stability of DNA duplex and its thermodynamics spectroscopically, caused by stretching and orientation of DNA strands in a microchannel laminar flow are elucidate and enthalpy-entropy compensation is applicable to the microfluidic thermal stability shift.
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Iodophenyl-conjugated closo-dodecaborate as a promising small boron molecule that binds to serum albumin and accumulates in tumor.
Kai Nishimura,Suzanna Harrison,Kazuki Kawai,Taiki Morita,Kazuki Miura,Satoshi Okada,Hiroyuki Nakamura +6 more
TL;DR: In this article , a boron-conjugated 4-iodophenylbutanamide (BC-IP) was used as an albumin ligand and conjugated with closo-dodecaborate, which was found to be water soluble with low cytotoxicity.
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