Hiroyuki Nakamura
Tokyo Institute of Technology
543 Papers
3.6K Citations
Hiroyuki Nakamura is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Chemistry & Catalysis. The author has an hindex of 52, co-authored 491 publications. Previous affiliations of Hiroyuki Nakamura include Japanese Foundation for Cancer Research & University of Tokyo.
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Papers
Rhodium(III)-catalysed decarboxylative C–H functionalization of isoxazoles with alkenes and sulfoxonium ylides
TL;DR: Decarboxylative C-H functionalization of isoxazoles with electron-deficient alkenes and sulfoxonium ylides at the C5 position was achieved in the presence of rhodium(iii) catalysts to give the corresponding alkenylation and acylmethylation products, respectively.
Photodynamic Therapy by Glucose Transporter 1-Selective Light Inactivation
TL;DR: 8 has a GLUT1-specific inactivation ability and causes light-induced cytotoxicity by modulating the EGFR/MAPK signaling pathway, indicating that 4-sulfamoylbenzoic acid 1 is a suitable photosensitizer for PDT.
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis.
T. Taniguchi,Takashi Kobayashi,J. Kondo,K. Takahashi,Hiroyuki Nakamura,J. Suzuki,K. Nagai,Takechiyo Yamada,S. Nakamura,Hirohei Yamamura +9 more
TL;DR: The 40-k da kinase was generated by proteolysis from the 72-kDa holoprotein which was a new member of nonreceptor protein-tyrosine kinase so far reported.
Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors.
TL;DR: The indenopyrazole framework was investigated as a new class of HIF-1α inhibitors and found to most strongly inhibit the hypoxia-induced Hif-1 α transcriptional activity among all of the known compounds having relatively simple structures, unlike manassantins.