Hiroyuki Miyachi
University of Tokyo
102 Papers
1.1K Citations
Hiroyuki Miyachi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Receptor. The author has an hindex of 30, co-authored 98 publications. Previous affiliations of Hiroyuki Miyachi include Massachusetts Institute of Technology & Okayama University.
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Papers
Suppression of β-catenin signaling by liver X receptor ligands
Shigeyuki Uno,Kaori Endo,Yangsik Jeong,Katsuyoshi Kawana,Hiroyuki Miyachi,Yuichi Hashimoto,Makoto Makishima +6 more
TL;DR: LXR activation suppresses the transactivation activity of beta-catenin, a key molecule in Wnt signaling and lipid-sensing receptor LXRs regulate the beta-Catenin activity and cellular proliferation.
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Design, Synthesis, and Evaluation of Substituted Phenylpropanoic Acid Derivatives as Human Peroxisome Proliferator Activated Receptor Activators. Discovery of Potent and Human Peroxisome Proliferator Activated Receptor α Subtype-Selective Activators
Masahiro Nomura,Takahiro Tanase,Tomohiro Ide,Masaki Tsunoda,Masahiro Suzuki,Hideharu Uchiki,Koji Murakami,Hiroyuki Miyachi +7 more
TL;DR: The identification of potent and human PPARalpha selective optically active alpha-alkylphenylpropanoic acid derivatives, which will be useful not only as pharmacological tools to investigate the physiology and pathophysiology of PPAR alpha but also as candidate drugs for the treatment of altered metabolic homeostasis, such as dyslipidemia, obesity, and diabetes.
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Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide
Rumiko Shimazawa,Hiroyuki Miyachi,Hisae Takayama,Kensei Kuroda,Fuminori Kato,Masanari Kato,Yuichi Hashimoto +6 more
TL;DR: Novel tumor necrosis factor-alpha production regulators with a phthalimide skeleton derived from thalidomide are shown to be more potent inhibitors of angiogenesis induced by basic fibroblast growth factor in a murine angiogenic assay.
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Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis
TL;DR: Studies on the molecular design of nuclear receptor antagonists, including retinoic acid receptor (RAR) antagonists, retinoid X receptors (RXR), androgen receptor (AR), and vitamin D receptor (VDR), based on inhibition of folding of helix 12 are reviewed.
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Tumor necrosis factor-alpha production-inhibiting activity of phthalimide analogues on human leukemia THP-1 cells and a structure-activity relationship study
TL;DR: A structure-activity relationship study of these phthalimide analogues revealed that their inhibitory effects on TPA- and OA-induced TNF-alpha production by THP-1 cells are well correlated to each other, i.e. they may involve the same target molecule(s).
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