Hiroyuki Arai
University of Tokyo
934 Papers
7K Citations
Hiroyuki Arai is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 108, co-authored 891 publications. Previous affiliations of Hiroyuki Arai include Obihiro University of Agriculture and Veterinary Medicine & University of Pennsylvania.
Chat about Author
Papers
Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells
Tatsuyuki Matsudaira,Kojiro Mukai,Taishin Noguchi,Junya Hasegawa,Tomohisa Hatta,Shun-ichiro Iemura,Tohru Natsume,Norio Miyamura,Hiroshi Nishina,Jun Nakayama,Kentaro Semba,Takuya Tomita,Shigeo Murata,Hiroyuki Arai,Hiroyuki Arai,Tomohiko Taguchi +15 more
TL;DR: It is shown that phosphatdylserine at recycling endosomes regulates YAP signalling pathway and suggests a link between a membrane phospholipid and cell proliferation.
Expression of multiple cbb3 cytochrome c oxidase isoforms by combinations of multiple isosubunits in Pseudomonas aeruginosa
TL;DR: This work shows that the opportunistic human pathogen Pseudomonas aeruginosa has a capability to produce 16 different cbb3 isoforms by combinations of multiple isosubunits, which indicate that P. aerug inosa gains resistance to respiratory inhibitors using multiple cbb 3 isoforms with different features, which are produced through exchanges of multiple core catalytic isosUBunits.
Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain.
Ryuichi Harada,Nobuyuki Okamura,Shozo Furumoto,Takeo Yoshikawa,Hiroyuki Arai,Kazuhiko Yanai,Yukitsuka Kudo +6 more
TL;DR: Multispectral imaging with BF-188 could potentially be used for selective in vivo imaging of tau deposits as well as amyloid-β in the brain.
Expression of the nir and nor genes for denitrification of Pseudomonas aeruginosa requires a novel CRP/FNR‐related transcriptional regulator, DNR, in addition to ANR
TL;DR: This is the first finding that two CRP/FNR‐related regulators are involved in denitrification in one strain of Pseudomonas aeruginosa.
Role of Phosphatidylethanolamine Biosynthesis in Herpes Simplex Virus 1-Infected Cells in Progeny Virus Morphogenesis in the Cytoplasm and in Viral Pathogenicity In Vivo.
Jun Arii,Ayano Fukui,Yuta Shimanaka,Nozomu Kono,Hiroyuki Arai,Yuhei Maruzuru,Naoto Koyanagi,Akihisa Kato,Yasuko Mori,Yasushi Kawaguchi +9 more
TL;DR: The results showed that inhibition of Pcyt2, a key cell enzyme for PE synthesis, significantly inhibited HSV-1 replication and pathogenicity in mice, suggesting that the PE biosynthetic pathway can be a target for the development of novel anti-HSV drugs.