Hiroyasu Yamamoto
École Polytechnique Fédérale de Lausanne
25 Papers
38 Citations
Hiroyasu Yamamoto is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 16 publications. Previous affiliations of Hiroyasu Yamamoto include French Institute of Health and Medical Research.
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Papers
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles Thomas,Antimo Gioiello,Lilia G. Noriega,Lilia G. Noriega,Axelle Strehle,Julien Oury,Giovanni Rizzo,Antonio Macchiarulo,Hiroyasu Yamamoto,Hiroyasu Yamamoto,Chikage Mataki,Chikage Mataki,Mark Pruzanski,Roberto Pellicciari,Johan Auwerx,Johan Auwerx,Kristina Schoonjans,Kristina Schoonjans +17 more
TL;DR: It is shown here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice, and suggested that pharmacological targeting of T GR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.
1.7K
The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity
Carles Cantó,Riekelt H. Houtkooper,Eija Pirinen,Eija Pirinen,Dou Yeon Youn,Maaike H. Oosterveer,Yana Cen,Pablo J. Fernandez-Marcos,Hiroyasu Yamamoto,Pénélope Andreux,Philippe Cettour-Rose,Karl Gademann,Chris Rinsch,Kristina Schoonjans,Anthony A. Sauve,Johan Auwerx +15 more
TL;DR: It is shown that NR supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.
1.1K
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Péter Bai,Péter Bai,Carles Cantó,Hugues Oudart,Attila Brunyanszki,Yana Cen,Charles Thomas,Hiroyasu Yamamoto,Aline Huber,Borbála Kiss,Riekelt H. Houtkooper,Kristina Schoonjans,Valérie Schreiber,Anthony A. Sauve,Josiane Ménissier-de Murcia,Johan Auwerx +15 more
TL;DR: The deletion of the poly(ADP-ribose) polymerase-1 (PARP-1) gene, encoding a major NAD(+)-consuming enzyme, increases NAD(+) content and SIRT1 activity in brown adipose tissue and muscle and the pharmacologic inhibition of PARP in vitro and in vivo is shown.
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Sirtuin Functions in Health and Disease
TL;DR: The wide range of cellular activities of the sirtuins suggests that they could constitute therapeutic targets to combat metabolic, neurodegenerative, and proliferative diseases.
NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
Hiroyasu Yamamoto,Evan G. Williams,Laurent Mouchiroud,Carles Cantó,Weiwei Fan,Michael Downes,Christophe Héligon,Grant D. Barish,Béatrice Desvergne,Ronald M. Evans,Kristina Schoonjans,Johan Auwerx +11 more
TL;DR: It is shown that muscle-specific loss of nuclear receptor corepressor 1 in mice leads to enhanced exercise endurance due to an increase of both muscle mass and of mitochondrial number and activity, suggesting that NCoR1 plays an adaptive role in muscle physiology and that interference with N coR1 action could be used to improve muscle function.
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