Hiroto Hayashi
Kanazawa University
5 Papers
Hiroto Hayashi is an academic researcher from Kanazawa University. The author has contributed to research in topics: Insulin receptor & Insulin resistance. The author has an hindex of 4, co-authored 5 publications.
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Papers
A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance
Hirofumi Misu,Toshinari Takamura,Hiroaki Takayama,Hiroto Hayashi,Naoto Matsuzawa-Nagata,Seiichiro Kurita,Kazuhide Ishikura,Hitoshi Ando,Yumie Takeshita,Tsuguhito Ota,Masaru Sakurai,Tatsuya Yamashita,Eishiro Mizukoshi,Taro Yamashita,Masao Honda,Ken-ichi Miyamoto,Tetsuya Kubota,Naoto Kubota,Takashi Kadowaki,Han Jong Kim,Inkyu Lee,Yasuhiko Minokoshi,Yoshiro Saito,Kazuhiko Takahashi,Yoshihiro Yamada,Nobuyuki Takakura,Shuichi Kaneko +26 more
TL;DR: It is demonstrated that selenoprotein P (SeP), a liver-derived secretory protein, causes insulin resistance and suggested that SeP may be a therapeutic target for type 2 diabetes.
559
LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance
Fei Lan,Hirofumi Misu,Keita Chikamoto,Hiroaki Takayama,Akihiro Kikuchi,Kensuke Mohri,Noboru Takata,Hiroto Hayashi,Naoto Matsuzawa-Nagata,Yumie Takeshita,Hiroyo Noda,Yukako Matsumoto,Tsuguhito Ota,Toru Nagano,Masatoshi Nakagen,Ken-ichi Miyamoto,Kanako Takatsuki,Toru Seo,Kaito Iwayama,Kunpei Tokuyama,Seiichi Matsugo,Hong Tang,Yoshiro Saito,Satoshi Yamagoe,Shuichi Kaneko,Toshinari Takamura +25 more
TL;DR: It is demonstrated that leukocyte cell–derived chemotaxin 2 (LECT2), an energy-sensing hepatokine, is a link between obesity and skeletal muscle insulin resistance and suggested that LECT2 may be a therapeutic target for obesity-associated insulin resistance.
149
Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver
Toshiki Otoda,Toshinari Takamura,Hirofumi Misu,Tsuguhito Ota,Shigeo Murata,Hiroto Hayashi,Hiroaki Takayama,Akihiro Kikuchi,Takehiro Kanamori,Kosuke R. Shima,Fei Lan,Takashi Takeda,Seiichiro Kurita,Kazuhide Ishikura,Yuki Kita,Kaito Iwayama,Ken-ichiro Kato,Masafumi Uno,Yumie Takeshita,Miyuki Yamamoto,Kunpei Tokuyama,Shoichi Iseki,Keiji Tanaka,Shuichi Kaneko +23 more
TL;DR: The data suggest that proteasome dysfunction mediates obesity-induced ER stress, leading to insulin resistance in the liver.
123
Severe veno-occlusive disease/sinusoidal obstruction syndrome after deceased-donor and living-donor liver transplantation.
Hiroyuki Takamura,Sinichi Nakanuma,Hiroto Hayashi,Hidehiro Tajima,Kaheita Kakinoki,Masaaki Kitahara,Seisyo Sakai,Isamu Makino,Hisatoshi Nakagawara,Tomoharu Miyashita,Kouichi Okamoto,Keishi Nakamura,Kaeko Oyama,Masashi Inokuchi,Itasu Ninomiya,H Kitagawa,Sachio Fushida,Takashi Fujimura,Ichiro Onishi,Masato Kayahara,Takashi Tani,Kuniaki Arai,Taro Yamashita,Tatsuya Yamashita,H. Kitamura,Hiroko Ikeda,Syuichi Kaneko,Yasuni Nakanuma,Osamu Matsui,T. Ohta +29 more
- 01 Dec 2014
TL;DR: The extrasinusoidal platelet activation, aggregation, and phagocytosis of platelets were some of the main reasons for VOD/SOS and transfusion-resistant thrombocytopenia and sustained sinusoidal endothelial cells injury resulted in bleeding in the space of Disse and led to around centrilobular hemorrhagic necrosis.
31
Von Willebrand Factor Deposition and ADAMTS-13 Consumption in Allograft Tissue of Thrombotic Microangiopathy-like Disorder After Living Donor Liver Transplantation: A Case Report.
Sinichi Nakanuma,Tomoharu Miyashita,Hiroto Hayashi,Yoshinao Ohbatake,Hiroyuki Takamura,Mitsuyoshi Okazaki,Takahisa Yamaguchi,Seisyo Sakai,Isamu Makino,Kaeko Oyama,Hidehiro Tajima,Itasu Ninomiya,Sachio Fushida,T. Ohta +13 more
- 01 Sep 2017
TL;DR: Findings suggest that EPA indicated sinusoidal endothelial cell damage followed by detachment, and vWF deposition resulted from UL-vWFM oversynthesis, which suggests ADAMTS-13 levels might be insufficient to cleave all the deposited UL- vWFMs.
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