Hirotaka Watada
Juntendo University
562 Papers
2.6K Citations
Hirotaka Watada is an academic researcher from Juntendo University. The author has contributed to research in topics: Diabetes mellitus & Medicine. The author has an hindex of 67, co-authored 460 publications. Previous affiliations of Hirotaka Watada include Osaka University & University of California, San Francisco.
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Papers
Repetitive Hypoglycemia Increases Circulating Adrenaline Level with Resultant Worsening of Intimal Thickening After Vascular Injury in Male Goto-Kakizaki Rat Carotid Artery
Eisuke Yasunari,Tomoya Mita,Yusuke Osonoi,Kosuke Azuma,Hiromasa Goto,Chie Ohmura,Akio Kanazawa,Ryuzo Kawamori,Yoshio Fujitani,Hirotaka Watada +9 more
TL;DR: Increased adrenaline induced by repetitive hypoglycemia promotes intimal thickening and smooth muscle cell proliferation after endothelial denudation in GK rats, and is abrogated by bunazosin.
Angiotensin II type 1 receptor blocker reduces monocyte adhesion to endothelial cells in spontaneously hypertensive rats
Fuki Ikeda,Kosuke Azuma,Takeshi Ogihara,Yukiko Toyofuku,Aiko Otsuka,Tomoya Mita,Takahisa Hirose,Yasushi Tanaka,Ryuzo Kawamori,Hirotaka Watada +9 more
TL;DR: It is confirmed that the reduction of blood pressure is effective method to reduce monocyte adhesion and demonstrated that valsartan has a modest beneficial effect on monocytes adhesion to endothelial cells and arterial intima-medial vessel thickening beyond its action as an antihypertensive agent.
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Type 2 diabetes and heart failure: insights from the global DISCOVER study.
Suzanne V. Arnold,Kamlesh Khunti,Fabrice Bonnet,Bernard Charbonnel,Hungta Chen,Javier Cid-Ruzafa,Andrew Cooper,Peter Fenici,Marília B. Gomes,Niklas Hammar,Linong Ji,Gabriela Luporini‐Saraiva,Jesús Medina,Antonio Nicolucci,Larisa Ramirez,Marina Vladimirovna Shestakova,Iichiro Shimomura,Filip Surmont,Fengming Tang,Jiten Vora,Hirotaka Watada,Mikhail Kosiborod +21 more
TL;DR: The DISCOVER study as discussed by the authors examined the global prevalence of heart failure and the incidence of HF over 3 years of follow-up in patients with Type 2 diabetes (T2D) [by presence and absence of co-existing coronary artery disease (CAD).
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Calcium channel blocker, azelnidipine, reduces lipid hydroperoxides in patients with type 2 diabetes independent of blood pressure.
Chie Ohmura,Hirotaka Watada,Tomoaki Shimizu,Ken Sakai,Hiroshi Uchino,Yoshio Fujitani,Akio Kanazawa,Takahisa Hirose,Ryuzo Kawamori +8 more
TL;DR: The data confirm the usefulness of lipid hydroperoxides in erythrocyte membrane as a marker of oxidative stress in vivo, and indicate that azelnidipine has a unique antioxidative property in human.
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Overexpression of acetyl-coenzyme A carboxylase beta increases proinflammatory cytokines in cultured human renal proximal tubular epithelial cells
TL;DR: An excess of ACACB results in increased proinflammatory cytokine expression, such as IL-6, at least partly by increasing mRNA stability through a p38 MAPK-dependent pathway.
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