Hiroshi Yamaguchi
Stanford University
16 Papers
20 Citations
Hiroshi Yamaguchi is an academic researcher from Stanford University. The author has contributed to research in topics: Inflammation & Apoptosis. The author has an hindex of 9, co-authored 16 publications. Previous affiliations of Hiroshi Yamaguchi include Kyoto University & Osaka University.
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Papers
Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression
Shi-Bin Li,Jeremy C. Borniger,Hiroshi Yamaguchi,Julien Hedou,Brice Gaudilliere,Luis de Lecea +5 more
TL;DR: These findings suggest both central and peripheral systems are synergistically engaged in the response to stress via CRHPVN circuitry and that restraint stress leads to hyperarousal associated with strong activation of corticotropin-releasing hormone neurons in the paraventricular nucleus of hypothalamus.
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In vitro and in vivo evaluation of the efficacy of bovine colostrum against human rotavirus infection.
Mizuho Inagaki,Mayumi Yamamoto,Xijier,Cairangzhuoma,Kenji Uchida,Hiroshi Yamaguchi,Mihoko Kawasaki,Kousaku Yamashita,Tomio Yabe,Yoshihiro Kanamaru +9 more
TL;DR: It is found that skimmed and concentrated bovine late colostrum obtained from normal cows at 6–7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro.
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Serum milk fat globule epidermal growth factor 8 elevation may subdivide systemic lupus erythematosus into two pathophysiologically distinct subsets
Naoki Yamamoto,Hiroshi Yamaguchi,Koichiro Ohmura,Tomoko Yokoyama,Hajime Yoshifuji,Naoichiro Yukawa,Daisuke Kawabata,Takao Fujii,Satoshi Morita,Shigekazu Nagata,Tsuneyo Mimori +10 more
TL;DR: MFG-E8-positive SLE and -negative SLE may have different clinical features, the one with stronger immunological response and the other with stronger inflammatory response, and those two groups may be two distinct subtypes of SLE driven by different mechanisms.
In vivo cell type-specific CRISPR gene editing for sleep research
Hiroshi Yamaguchi,Luis de Lecea +1 more
TL;DR: The background of newly developed gene-editing technologies using engineered CRISPR/Cas9 system is reviewed and the application to interrogate gene functions within genetically-defined brain cell populations in sleep research is described.
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Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression
Shi-Bin Li,Jeremy C. Borniger,Hiroshi Yamaguchi,Julien H eacutedou,Brice Gaudilli egravere,Luis de Lecea +5 more
TL;DR: Both central and peripheral systems are synergistically engaged in the response to stress via CRHPVN circuitry, and single-cell mass cytometry by time of flight (CyTOF) is used to analyze peripheral blood and found extensive changes to immune cell distribution and functional responses during wakefulness upon optogenetic stimulation of CRHPvN neurons.
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