Hiroshi Kitamura
Tohoku University
17 Papers
41 Citations
Hiroshi Kitamura is an academic researcher from Tohoku University. The author has contributed to research in topics: Chemistry & Cancer cell. The author has an hindex of 9, co-authored 17 publications. Previous affiliations of Hiroshi Kitamura include National Defense Medical College.
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Papers
NRF2 addiction in cancer cells.
TL;DR: This review introduces recent studies describing the development and characterization of NRF2‐addicted cancers, as well as their potential therapeutic targets and expected advances in diagnostic and therapeutic interventions.
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Autophagy regulates lipid metabolism through selective turnover of NCoR1
Tetsuya Saito,Akiko Kuma,Akiko Kuma,Yuki Sugiura,Yoshinobu Ichimura,Miki Obata,Hiroshi Kitamura,Shujiro Okuda,Hyeon-Cheol Lee,Kazutaka Ikeda,Yumi Kanegae,Izumu Saito,Johan Auwerx,Hozumi Motohashi,Makoto Suematsu,Tomoyoshi Soga,Takehiko Yokomizo,Satoshi Waguri,Noboru Mizushima,Masaaki Komatsu,Masaaki Komatsu +20 more
TL;DR: It is shown that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and the production of ketone bodies.
Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
Keito Okazaki,Hayato Anzawa,Zun Liu,Nao Ota,Hiroshi Kitamura,Yoshiaki Onodera,Md. Morshedul Alam,Daisuke Matsumaru,Takuma Suzuki,Fumiki Katsuoka,Shu Tadaka,Ikuko N. Motoike,Mika Watanabe,Kazuki Hayasaka,Akira Sakurada,Yoshinori Okada,Masayuki Yamamoto,Takashi Suzuki,Kengo Kinoshita,Hiroki Sekine,Hozumi Motohashi +20 more
TL;DR: It is found that persistently activated NRF2 in NSCLCs generates enhancers at gene loci that are not normally regulated by transiently activatedNRF2 under physiological conditions, and the NOTCH3 enhancer is shown to be critical for promotion of tumor-initiating activity.
IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model
TL;DR: A significant correlation between NRF2 and IL-11 status in breast cancer patients is found and the first report showing the influence of the microenvironment on theNRF2 pathway in cancer cells and the contribution of NRf2 to the secretory phenotypes of cancers is shown.
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Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors
Makiko Hayashi,Ayumi Kuga,Mikiko Suzuki,Harit Panda,Hiroshi Kitamura,Hozumi Motohashi,Masayuki Yamamoto +6 more
TL;DR: It is demonstrated that microenvironmental Nrf2 activation suppresses the progression of malignant NRF2-activated tumors and that Nrf 2 activation in immune cells at least partially contributes to these suppressive effects.