Hiroshi Kanamaru
Sumitomo Chemical
35 Papers
137 Citations
Hiroshi Kanamaru is an academic researcher from Sumitomo Chemical. The author has contributed to research in topics: Pharmacokinetics & Vitamin D and neurology. The author has an hindex of 9, co-authored 34 publications.
Chat about Author
Papers
Characterization of the enzymes involved in the in vitro metabolism of amrubicin hydrochloride.
TL;DR: The in vitro metabolism of amrubicin by rat and human liver microsomes and cytosol was examined and the main metabolic route of this active metabolite was reductive deglycosylation and carbonyl group reduction in the side-chain.
31
Tissue distribution and pharmacological potential of SM-16896, a novel oestrogen-bisphosphonate hybrid compound.
Naomi Tsushima,Masashi Yabuki,Hideyuki Harada,Takashi Katsumata,Hiroshi Kanamaru,Iwao Nakatsuka,Michihiro Yamamoto,Masashi Nakatsuka +7 more
TL;DR: This work has synthesized and evaluated the effects of a novel hybrid compound of oestrogen and bisphosphonate, SM‐16896, and the tissue distribution pattern and pharmacological potential are reported.
31
14C‐labeling of a novel atypical β‐adrenoceptor agonist, SM‐11044
TL;DR: In this article, a pyrrolidine amide hydrobromide (SM-11044) was synthesized for mammalian metabolic studies using the Grignard reaction of 3,4-methylenedioxy-phenylmagnesium bromide with carbon dioxide liberated from barium [14C] carbonate.
19
In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-F6-1,25(OH)2 vitamin D3 (Falecalcitriol) in rat: induction of vitamin D3-24-hydroxylase (CYP24) responsible for 23S-hydroxylation in target tissues and the drop in serum levels.
TL;DR: The results indicate that in vivo metabolism of F6-1,25(OH)2 vitamin D3 to F6 -1,23S,25 (OH)3 vitamin D 3 is catalysed by CYP24, the enzyme being induced by prior substrate exposure.
16
Distribution and metabolism of F6-1,25(OH)2 Vitamin D3 and 1,25(OH)2 Vitamin D3 in the bones of rats dosed with tritium-labeled compounds
TL;DR: In this article, the authors compared the distribution and metabolism of [1β- 3 H]F 6 -1,25(OH) 2 vitamin D 3 in bones of rats by autoreadiography and radio-HPLC.
15