Hiroshi Inoue
Osaka Dental University
64 Papers
106 Citations
Hiroshi Inoue is an academic researcher from Osaka Dental University. The author has contributed to research in topics: Cell culture & Stimulation. The author has an hindex of 9, co-authored 64 publications.
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Papers
Fractalkine-Mediated Endothelial Cell Injury by NK Cells
Osamu Yoneda,Toshio Imai,Seiji Goda,Hiroshi Inoue,Akira Yamauchi,Toshio Okazaki,Hisao Imai,Osamu Yoshie,Eda T. Bloom,Naochika Domae,Hisanori Umehara +10 more
TL;DR: The results suggest that fractalkine plays an important role not only in the binding of NK cells to endothelial cells, but also in NK cell-mediated endothelium damage, which may result in vascular injury.
211
Lipid rafts as the signaling scaffold for NK cell activation: tyrosine phosphorylation and association of LAT with phosphatidylinositol 3‐kinase and phospholipase C‐γ following CD2 stimulation
Hiroshi Inoue,Michihiko Miyaji,Michihiko Miyaji,Atsushi Kosugi,Masakazu Nagafuku,Toshiro Okazaki,Tsuneyo Mimori,Ryuichi Amakawa,Shirou Fukuhara,Naochika Domae,Eda T. Bloom,Hisanori Umehara,Hisanori Umehara +12 more
TL;DR: Modulation of raft integrity by aggregation of NK cell activating receptors, which leads to the formation of complexes of LAT with PI 3‐K and PLC‐γ1, is essential for the NK cell lytic mechanisms.
62
Heparin-binding epidermal growth factor-like growth factor is a potent regulator of invasion activity in oral squamous cell carcinoma
TL;DR: Data indicate that HB-EGF released from HSC3 cells by TACE stimulates EGFR in an autocrine manner, which in turn activates invasion activity via MMP-9 upregulation.
Role for adapter proteins in costimulatory signals of CD2 and IL-2 on NK cell activation.
Hisanori Umehara,Hiroshi Inoue,J Y Huang,Takeshi Kono,Yasuhiro Minami,Yoshiya Tanaka,Toshiro Okazaki,Tsuneyo Mimori,Eda T. Bloom,Naochika Domae +9 more
TL;DR: In this paper, the role of adapter proteins in the increased NK activation following CD2 crosslinking and IL-2 stimulation of NK3.3 cells was examined, and it was shown that interaction of Grb2-Shc and CrkL-Cbl were mediated through each SH2 domain in tyrosine phosphorylation-dependent manner.
13
Sevoflurane confers additive cardioprotection to ethanol preconditioning associated with enhanced phosphorylation of glycogen synthase kinase-3β and inhibition of mitochondrial permeability transition pore opening.
Anna Onishi,Masami Miyamae,Hiroshi Inoue,Kazuhiro Kaneda,Chika Okusa,Yoshitaka Inamura,Mayumi Shiomi,Shizuka Koshinuma,Yoshihiro Momota,Vincent M. Figueredo +9 more
TL;DR: SEVO and chronic EtOH preconditioning offer additive cardioprotection and this effect is associated with an increased GSK-3β phosphorylation and an inhibition of MPTP opening.
10