Hiroshi Iijima
Nihon University
44 Papers
391 Citations
Hiroshi Iijima is an academic researcher from Nihon University. The author has contributed to research in topics: Chemistry & Peptide sequence. The author has an hindex of 16, co-authored 41 publications. Previous affiliations of Hiroshi Iijima include University of Tokyo & University of British Columbia.
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Papers
Design and synthesis of Rho kinase inhibitors (I)
Atsuya Takami,Masayuki Iwakubo,Yuji Okada,Takehisa Kawata,Hideharu Odai,Nobuaki Takahashi,Kazutoshi Shindo,Kaname Kimura,Yoshimichi Tagami,Mika Miyake,Kayoko Fukushima,Masaki Inagaki,Mutsuki Amano,Kozo Kaibuchi,Hiroshi Iijima +14 more
TL;DR: Several structurally unrelated scaffolds of the RhoKinase inhibitor were designed using pharmacophore information obtained from the results of a high-throughput screening and structural information from a homology model of Rho kinase to comprehensively understand and predict the structure-activity relationship of the inhibitors.
175
Patent
Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
Atsuya Takami,Hiroshi Iijima,Masayuki Iwakubo,Yuji Okada +3 more
- 01 Feb 2001
TL;DR: In this article, the Rho kinase inhibitory activity of compounds of general formula (I): Het-X-Z, pharmaceutically acceptable salts thereof and solvates of the same, wherein Het represents a monocyclic or dicyclic heterocycle group containing at least one nitrogen atom (for example, pyridyl, phthalimido), X represents (i) an -NH-C(=O)-NH-Q1-group, and Z represents hydrogen, halogeno, a moncyclic,
120
High-level expression of a sweet protein, monellin, in the food yeast Candida utilis
TL;DR: Heterologous expression of monellin in the yeast Candida utilis showed high-copy-number integration of vectors into either the rDNA locus or the URA3 gene locus, accounting for >50% of the soluble protein.
87
Calibration of effective van der Waals atomic contact radii for proteins and peptides.
TL;DR: Effective van der Waals radii were celebrated in such a way that molecular models built from standard bond lengths and bond angels reproduced the amino acid conformations observed by crystallography in proteins and peptides.
74