Hiroshi Fujii
Kyoto Prefectural University of Medicine
49 Papers
1K Citations
Hiroshi Fujii is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Leukemia & Multiple myeloma. The author has an hindex of 15, co-authored 49 publications. Previous affiliations of Hiroshi Fujii include Hitachi.
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Papers
Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
Shigeo Horiike,Shouhei Yokota,Mitsushige Nakao,Toshiki Iwai,Y Sasai,Hiroto Kaneko,Masafumi Taniwaki,Kei Kashima,Hiroshi Fujii,Tatsuo Abe,Shinichi Misawa +10 more
TL;DR: The fact that the accumulation of genetic events, including FLT3 duplication, correlates with leukemic transformation from antecedent myelodysplasia and with subsequent disease progression is uncovered.
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Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism
Tatsuo Ichinohe,Takashi Uchiyama,Chihiro Shimazaki,Keitaro Matsuo,Shigehisa Tamaki,Masayuki Hino,Arata Watanabe,Motohiro Hamaguchi,Souichi Adachi,Hisashi Gondo,Nobuhiko Uoshima,Takao Yoshihara,Kazuo Hatanaka,Hiroshi Fujii,Keisei Kawa,Kazunobu Kawanishi,Koji Oka,Hideo Kimura,Mitsuru Itoh,Takeshi Inukai,Etsuko Maruya,Hiroh Saji,Yoshihisa Kodera +22 more
TL;DR: Results indicate that T cell-replete SCT from an HLA-haploidentical NIMA-mismatched donor can offer durable remission with an acceptable risk of GVHD in selected patients with advanced hematologic malignancies who lack immediate access to a conventional stem cell source.
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International prognostic scoring system and TP53 mutations are independent prognostic indicators for patients with myelodysplastic syndrome.
Yuri Kita-Sasai,Shigeo Horiike,Shinichi Misawa,Hiroto Kaneko,Miyako Kobayashi,Mitsushige Nakao,Hitoshi Nakagawa,Hiroshi Fujii,Masafumi Taniwaki +8 more
TL;DR: A combination of clinical manifestations and genetic configurations provided us with more accurate prognostic information in MDS patients and showed a significant difference in the intermediate subgroups.
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Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia.
Masafumi Taniwaki,Kohji Nishida,Takashima T,Hitoshi Nakagawa,Hiroshi Fujii,T Tamaki,Chihiro Shimazaki,Shigeo Horiike,Shinichi Misawa,Tatsuo Abe +9 more
TL;DR: The present findings suggest that there may be subsets of 14q32 translocations specific to MM, and that the short arm of chromosome 1 was preferentially involved in deletion, suggesting a certain antioncogene on 1p associated with the development of myeloma.
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Distinct genetic involvement of the TP53 gene in therapy-related leukemia and myelodysplasia with chromosomal losses of Nos 5 and/or 7 and its possible relationship to replication error phenotype.
Shigeo Horiike,Shinichi Misawa,Hiroto Kaneko,Y Sasai,Miyako Kobayashi,Hiroshi Fujii,S Tanaka,M Yagita,Tatsuo Abe,Kei Kashima,Masafumi Taniwaki +10 more
TL;DR: This study revealed a possible relationship of RER+ phenotype accompanying an hMSH2 alteration to the development of therapy-related AML/MDS in association with TP53 mutations and specific chromosomal losses, and suggests that some patients may be predisposed to myelodysplasia after chemotherapy for their primary tumor.
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