There is provided a nuclear reprogramming factor for a somatic cell, which comprises a gene product of each of the following three kinds of genes: an Oct family gene, a Klf family gene, and a Myc family gene, as a means for inducing reprogramming of a differentiated cell to conveniently and highly reproducibly establish an induced pluripotent stem cell having pluripotency and growth ability similar to those of ES cells without using embryo or ES cell.

Nuclear reprogramming factor

Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.

Multipotent/pluripotent cells and methods

The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.

Nuclear reprogramming factor and induced pluripotent stem cells

Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells

Methods and compositions for treating obesity and related disorders. The methods include the use of Sca- 1+ progenitor cells treated with BMP-2, -4, -5, -6, and/or -7.

Methods and compositions for inducing brown adipogenesis

Subjects of the present invention are to establish a technology for separating, isolating and culturing a stem cell derived from adult tissue while retaining the in vivo properties thereof, and to provide a preventive and/or therapeutic agent for diseases which accompany tissue injury, which comprises a stem cell derived from adult tissue as an active ingredient. In order to solve the subjects, the present invention provides a stem cell derived from adult tissue which is CD45-negative and CXCR4-positive. Also, the present invention provides a preventive and/or therapeutic agent for diseases which accompany tissue injury, which comprises the stem cell as an active ingredient.

Novel adult tissue-derived stem cell and use thereof

The present invention relates to an agent which mobilizes multipotential stem cells from tissues such as bone marrow, skin and skeletal muscle to peripheral blood. The present invention further relates to a method for the treatment of cardiac insufficiency, hepatic insufficiency, renal insufficiency, neurodegenerative diseases (such as Parkinson's disease and Alzheimer's disease), cardiovascular disturbance, cerebrovascular disturbance, spinal damage, arthritis, osteoporosis, diabetes mellitus, etc. using the agent which mobilizes multipotential stem cells from tissues such as bone marrow, skin and skeletal muscle to peripheral blood.

Drug mobilizing pluripotent stem cells from tissue into peripheral blood

There is established a technology for separating, isolating and culturing stem cells derived from adult tissue while retaining the in vivo properties thereof, and provided a preventive and/or therapeutic agent for diseases involving tissue disintegration, which comprises stem cells derived from adult tissue as an active ingredient. In particular, there are provided stem cells derived from adult tissue which are CD45 negative and CXCR4 positive and provided a preventive and/or therapeutic agent for diseases involving tissue disintegration, which comprises the above stem cells as an active ingredient.

Novel stem cell derived from adult tissue and use thereof

A preventive and/or a remedy for diseases accompanied by tissue destruction which contains a polypeptide having a granulocyte colony stimulating factor activity as the active ingredient; and a drug mobilizing pluripotent stem cells from a tissue toward peripheral blood which contains a polypeptide having a granulocyte colony stimulating factor activity as the active ingredient.

Preventive and/or remedy for diseases accompanied by tissue destruction

The present invention relates to an agent for preventing and/or treating diseases accompanied by tissue disruption, which comprises a polypeptide having granulocyte colony-stimulating factor activity as an active ingredient, and a medicament for mobilizing a multipotent stem cell from a tissue into peripheral blood, which comprises a polypeptide having granulocyte colony-stimulating factor activity as an active ingredient.

Agent for preventing and/or treating tissue disruption-accompanied diseases

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