Hiromitsu Takayama
Chiba University
246 Papers
1.8K Citations
Hiromitsu Takayama is an academic researcher from Chiba University. The author has contributed to research in topics: Indole alkaloid & Total synthesis. The author has an hindex of 43, co-authored 240 publications. Previous affiliations of Hiromitsu Takayama include National Institute of Radiological Sciences & University of Tokyo.
Chat about Author
Papers
Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells.
Junko Ogura,Mana Mitamura,Akiyoshi Someya,Ken Shimamura,Hiromitsu Takayama,Norio Aimi,Syunji Horie,Toshihiko Murayama +7 more
TL;DR: The findings suggest that mesaconitine stimulated Ca(2+) influx via the Na(+)/Ca( 2+) exchangers in endothelial cells and caused relaxation in the aorta.
11
Synthesis and absolute configuration of 9-β-D-glucosyloxycamptothecin, a new gluco camptothecin isolated from Ophiorrhiza pumila regenerated plants
TL;DR: In this article, the regenerated plantlets of Ophiorrhiza pumila have been synthesized and its structure and the absolute configuration established, and the 9-β-D-Glucosyloxycamptothecin has been obtained from the plantlets.
10
Formation of an unusual dimeric compound by lead tetraacetate oxidation of a corynanthe-type indole alkaloid, mitragynine.
TL;DR: Lead tetraacetate oxidation of a Corynanthe-type indole alkaloid produced mainly 7-acetoxyindolenine derivative together with a dimeric compound as a minor product.
10
Biphenyl ether and biphenyl quinolizidine lactone alkaloids from Heimia salicifolia
Mariko Kitajima,Tomomi Yanagisawa,Mari Tsukahara,Yasuka Yamaguchi,Noriyuki Kogure,Ruri Kikura-Hanajiri,Yukihiro Goda,Osamu Iida,Yasushi Sugimura,Nobuo Kawahara,Hiromitsu Takayama +10 more
TL;DR: In this article, three new biphenyl ether quinolizidine lactone alkaloids (1, 3) and 13 new quinoline lactone (4, 16) were isolated from Heimia salicifolia (Lythraceae) together with seven known alkaloid structures.
10
Asymmetric Total Synthesis and Evaluation of Antitumor Activity of Ophiorrhisine A and Its Derivatives
TL;DR: The structure-activity relationship study of ophiorrhisine A and its derivatives demonstrated that some derivatives possessed cytotoxicity toward human cancer cell lines A549, HT29, and HCT116.
10