Hiroko Tsukano
National Institutes of Health
4 Papers
6 Citations
Hiroko Tsukano is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Lipid A & Phagosome. The author has an hindex of 3, co-authored 4 publications.
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Papers
Yersinia pseudotuberculosis blocks the phagosomal acidification of B10.A mouse macrophages through the inhibition of vacuolar H(+)-ATPase activity.
Hiroko Tsukano,Fumiaki Kura,Satoru Inoue,Satoshi Sato,Hidemasa Izumiya,Tomoyoshi Yasuda,Haruo Watanabe +6 more
TL;DR: Results indicated that the inhibition of phagosomal acidification by Y. pseudotuberculosis infection was due to the attenuation of V-ATPase activity, and not to the exclusion of V -ATP enzyme subunits from the phagosome membrane as found in Mycobacterium avium.
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Therapeutic Effect of Antimicrobial Drugs against Experimental Infections Due to Yersinia pestis in Mice
TL;DR: There are several new drugs, both oral and injectable, which exert excellent in vivo antibacterial activity against a mouse infection model and may be useful for the clinical treatment of plague.
3
In Vitro Activity of Twenty-Three Antimicrobials Against Yersinia pestis Strains
TL;DR: The microdilution method was used to determine the MICs of twenty-three antimicrobials against the 22 strains of Yersinia pestis that have been stocked in the National Institute of Health, Japan, and the three fluoroquinolones, ofloxacin, ciprofl oxacin and sparfloxacins were most active.
3
Modification of the Structure and Activity of Lipid A in Yersinia pestis Lipopolysaccharide by Growth Temperature
TL;DR: The results suggest that in order to reduce the activation of human macrophages, it may be more advantageous for Y. pestis to produce less-acylated lipid A at 37°C.