Hiroko Endo
3 Papers
1 Citations
Hiroko Endo is an academic researcher. The author has contributed to research in topics: Proarrhythmia & hERG. The author has an hindex of 2, co-authored 3 publications.
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Papers
CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability-
Yumiko Nozaki,Yayoi Honda,Hitoshi Watanabe,Shota Saiki,Kiyotaka Koyabu,Tetsuji Itoh,Chiho Nagasawa,Chiaki Nakamori,Chiaki Nakayama,Hiroshi Iwasaki,Shinobu Suzuki,Ikumi Washio,Etsushi Takahashi,Kaori Miyamoto,Atsuhiro Yamanishi,Hiroko Endo,Junko Shinozaki,Hisashi Nogawa,Takeshi Kunimatsu +18 more
TL;DR: The new assay model reported here would enable accurate prediction of a drug potential for proarrhythmia in a multi-electrode array system used for in-vitro screening of hERG channels.
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CSAHi study: Usability assessment of multi-electrode array in combination with human iPS cell-derived cardiomyocytes for prediction of drug-induced QT prolongation and arrhythmia — Multi Channel Systems (MEA60 and MEA2100)
Takeshi Kunimatsu,Yumiko Nozaki,Yayoi Honda,Hitoshi Watanabe,Atsuhiro Yamanishi,Hisashi Nogawa,Hiroko Endo,Shota Saiki,Chiho Nagasawa,Chiaki Nakamori,Chiaki Nakayama,Hiroshi Iwasaki,Etsushi Takahashi,Kaori Miyamoto,Kaoru Morimura,Kohji Tanaka,Shinobu Suzuki,Ikumi Washio +17 more
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CSAHi study-2: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: Assessment of reference compounds and comparison with non-clinical studies and clinical information
Yumiko Nozaki,Yayoi Honda,Hitoshi Watanabe,Shota Saiki,Kiyotaka Koyabu,Tetsuji Itoh,Chiho Nagasawa,Chiaki Nakamori,Chiaki Nakayama,Hiroshi Iwasaki,Shinobu Suzuki,Kohji Tanaka,Etsushi Takahashi,Kaori Miyamoto,Kaoru Morimura,Atsuhiro Yamanishi,Hiroko Endo,Junko Shinozaki,Hisashi Nogawa,Tadahiro Shinozawa,Fumiyo Saito,Takeshi Kunimatsu +21 more
TL;DR: The hiPS‐CMs/MEA assay accurately predicted reference compounds potential for arrhythmogenesis, and yielded results that showed better correlation with target concentrations of QTc prolongation or TdP in clinical setting than other current in vitro and in vivo assays.