Hiroki Urabe
Taisho Pharmaceutical Co.
19 Papers
190 Citations
Hiroki Urabe is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Metabotropic glutamate receptor 2 & Hydroxamic acid. The author has an hindex of 7, co-authored 19 publications.
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Papers
Patent
Novel hydroxamic acid derivative
Hajime Takashima,Risa Tsuruta,Tetsuya Yabuuchi,Yusuke Oka,Hiroki Urabe,Yoichiro Suga,Masato Takahashi,Fumito Uneuchi,Hironori Kotsubo,Muneo Shoji,Yasuko Kawaguchi +10 more
- 20 Apr 2011
TL;DR: In this article, a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria.
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Neurophysiologic and Antipsychotic Profiles of TASP0433864, a Novel Positive Allosteric Modulator of Metabotropic Glutamate 2 Receptor
Tetsuaki Hiyoshi,Toshiyuki Marumo,Hirohiko Hikichi,Yasumitsu Tomishima,Hiroki Urabe,Tomoko Tamita,Izumi Iida,Akito Yasuhara,Jun-ichi Karasawa,Shigeyuki Chaki +9 more
TL;DR: Findings indicate that TASP0433864 is a selective mGlu2 receptor PAM with antipsychotic activity, and the attenuation of excess glutamatergic neurotransmission may be involved in the action of TASp04338 64.
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Patent
Novel nitrogenated heterocyclic compound and salt thereof
Taro Kiyoto,Tadashi Tanaka,Yasuhiro Tsutsui,Junichi Ando,Mai Motono,Yasuko Kawaguchi,Toshiya Noguchi,Yasunobu Ushiki,Fumihito Ushiyama,Hiroki Urabe +9 more
- 22 Jun 2006
TL;DR: A nitrogenated heterocyclic compound represented by the general formula: wherein the broken line represents a single bond or a double bond, R1, R2, R3, R4 and R5 independently represent a hydrogen or halogen atom, a lower alkyl, aryl, lower alkoxy or monocyclIC heter-cyclic group which may be substituted or the like.
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Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor.
Hirohiko Hikichi,Tetsuaki Hiyoshi,Toshiyuki Marumo,Yasumitsu Tomishima,Ayaka Kaku,Izumi Iida,Hiroki Urabe,Tomoko Tamita,Akito Yasuhara,Jun-ichi Karasawa,Shigeyuki Chaki +10 more
TL;DR: Findings indicate that TASP0443294 is an mGlu2 receptor positive allosteric modulator with antipsychotic activity, and that the suppression of aberrant gamma oscillations and REM sleep could be considered as neurophysiological biomarkers for TasP0 443294.
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Patent
Novel heterocyclic compound or salt thereof and intermediate thereof
Kiyoto Taro,Junichi Ando,Tadashi Tanaka,Yasuhiro Tsutsui,Mai Yokotani,Noguchi Toshiya,Fumihito Ushiyama,Hiroki Urabe,Horikiri Hiromasa +8 more
- 24 May 2007
Abstract: Disclosed is a compound represented by the general formula: [wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.
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