Hiroki Kumamoto
Showa University
70 Papers
414 Citations
Hiroki Kumamoto is an academic researcher from Showa University. The author has contributed to research in topics: Nucleoside & Radical cyclization. The author has an hindex of 15, co-authored 65 publications. Previous affiliations of Hiroki Kumamoto include University of Orléans & Centre national de la recherche scientifique.
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Papers
Anti-Human Immunodeficiency Virus Type 1 Activity and Resistance Profile of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine In Vitro
Takao Nitanda,Xin Wang,Hiroki Kumamoto,Kazuhiro Haraguchi,Hiromichi Tanaka,Yung-Chi Cheng,Masanori Baba +6 more
TL;DR: Since 4′-Ed4T has increased anti-HIV-1 activity, decreased cytotoxicity, and a different resistance profile, it should be considered for further development as a new member of NRTIs.
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Radical-mediated stannylation of vinyl sulfones: access to novel 4′-modified neplanocin A analogues
Hiroki Kumamoto,Kazuki Deguchi,Tadashi Wagata,Yuu Furuya,Yuki Odanaka,Yukio Kitade,Hiromichi Tanaka +6 more
TL;DR: In this paper, a cyclopentenol derivative having a vinyl stannane structure was designed as key-intermediate in this study, which was prepared based on radical-mediated sulfur-extrusive stannylation.
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A New Entry to 2-Substituted Purine Nucleosides Based on Lithiation-Mediated Stannyl Transfer of 6-Chloropurine Nucleosides
Keisuke Kato,Hiroyuki Hayakawa,Hiromichi Tanaka,Hiroki Kumamoto,Satoru Shindoh,Satoshi Shuto,Tadashi Miyasaka +6 more
TL;DR: In this paper, an anionic stannyl (or silyl) transfer from the 8-position of 9-(2,3,5-tris-O-TBDMS-β-d-ribofuranosyl)-6-chloropurine (2) with LDA, subsequent quenching of its lithiated species with Bu3SnCl (or TMSCl) results in the formation of 2substituted products.
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Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
Hiroki Kumamoto,Dimitri Topalis,Julie Broggi,Ugo Pradere,Vincent Roy,Sabine Berteina-Raboin,Steven P. Nolan,Dominique Deville-Bonne,Graciela Andrei,Robert Snoeck,Daniel Garin,Jean-Marc Crance,Luigi A. Agrofoglio +12 more
TL;DR: In this article, the synthesis of acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step was reported.
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Click Azide‐Alkyne Cycloaddition for the Synthesis of D‐(–)‐1,4‐Disubstituted Triazolo‐Carbanucleosides
Julie Broggi,Julie Broggi,Hiroki Kumamoto,Sabine Berteina-Raboin,Steven P. Nolan,Luigi A. Agrofoglio +5 more
TL;DR: In this paper, a revisited and improved synthesis of an optically active azido-carbanucleoside is reported, which is used in the successful and versatile synthesis of enantiomerically pure D-(−)-1,4-disubstituted 1,2,3-triazolo-CARBNsides via copper(I)-catalyzed and microwave-assistedHuisgen 1,3dipolar cycloaddition.
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