Hiltraud Hosser
Heidelberg University
15 Papers
110 Citations
Hiltraud Hosser is an academic researcher from Heidelberg University. The author has contributed to research in topics: Podocyte & Glomerular basement membrane. The author has an hindex of 12, co-authored 15 publications.
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Papers
Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells
Robert Koesters,Brigitte Kaissling,Michel LeHir,Nicolas Picard,Franziska Theilig,Rolf Gebhardt,Adam B. Glick,Brunhilde Hähnel,Hiltraud Hosser,Hermann Josef Gröne,Wilhelm Kriz +10 more
TL;DR: In conclusion, overexpression of TGF-beta1 in renal tubules in vivo induces interstitial proliferation, tubular autophagy, and fibrosis, but not epithelial-to-mesenchymal transition.
281
The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes
Claudia Rohr,Jürgen Prestel,Laurence Heidet,Hiltraud Hosser,Wilhelm Kriz,Randy L. Johnson,Corinne Antignac,Ralph Witzgall +7 more
TL;DR: It is demonstrated that Lmx1b regulates important steps in glomerular development and establishes a link between three hereditary kidney diseases: nail-patella syndrome, steroid-resistant nephrotic syndrome (podocin), and Alport syndrome (collagen IV alpha4).
Effects of Increased Renal Tubular Vascular Endothelial Growth Factor (VEGF) on Fibrosis, Cyst Formation, and Glomerular Disease
Samy Hakroush,Marcus J. Moeller,Franziska Theilig,Brigitte Kaissling,Tjeerd P. Sijmonsma,Manfred Jugold,Ann L. Akeson,Milena Traykova-Brauch,Hiltraud Hosser,Brunhilde Hähnel,Hermann Josef Gröne,Robert Koesters,Wilhelm Kriz +12 more
TL;DR: This study shows that systemic VEGF interferes with the intraglomerular cross-talk between podocytes and the endocapillary compartment, leading to severe deterioration in glomerular architecture, similar to that seen in diabetic nephropathy.
Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker rat
Nikolaus Gassler,Marlies Elger,Bettina Kränzlin,Wilhelm Kriz,Norbert Gretz,Brunhilde Hähnel,Hiltraud Hosser,Inge Hartmann +7 more
TL;DR: Nphron degeneration in the fa/fa Zucker rat is studied, which is considered to be a model for non-insulin-dependent diabetes mellitus, to ensure that the destructive effects remain confined to the initially affected nephron.
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Development of vascular pole-associated glomerulosclerosis in the Fawn-hooded rat.
TL;DR: A step-by-step sequence of histopathologic events leading from an initial glomerular injury to segmental sclerosis in the FHH rat is elucidated.