Hilde Dannenberg
Erasmus University Rotterdam
11 Papers
171 Citations
Hilde Dannenberg is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Germline mutation & SDHD. The author has an hindex of 10, co-authored 11 publications.
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Papers
Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas.
Hilde Dannenberg,Ernst J. M. Speel,Jianming Zhao,Parvin Saremaslani,Erwin van der Harst,Jürgen Roth,Philipp U. Heitz,H. Jaap Bonjer,Winand N.M. Dinjens,Wolter J. Mooi,Paul Komminoth,Ronald R. de Krijger +11 more
TL;DR: The results suggest that the development of pheochromocytomas is associated with specific genomic aberrations, such as losses of 1p, 3q, and 6q and gains of 9q and 17q and aneuploidy in some tumors.
•Journal Article
Frequent germ-line succinate dehydrogenase subunit D gene mutations in patients with apparently sporadic parasympathetic paraganglioma.
Hilde Dannenberg,Winand N.M. Dinjens,Mustaffa Abbou,Hero van Urk,Bernard K. H. Pauw,Diane Mouwen,Wolter J. Mooi,Ronald R. de Krijger +7 more
TL;DR: Germ-line mutations of the SDHD gene are present in a significant number of patients with apparently sporadic parasympathetic PGL, and somatic SDHD mutations do not play a significant role in the sporadic form of this tumor.
Clinical Characteristics of Pheochromocytoma Patients With Germline Mutations in SDHD
Hilde Dannenberg,Francien H van Nederveen,Mustaffa Abbou,Albert A.J. Verhofstad,Paul Komminoth,Ronald R. de Krijger,Winand N.M. Dinjens +6 more
TL;DR: SDHD gene mutations in patients presenting with apparently sporadic adrenal pheochromocytoma are rare and recommend SDHD mutation screening for patientsPresenting with a family history of phechromocyToma or PGL, multiple tumors, isolated adrenal or extra-adrenal p heochROMocytomas, and age
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Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p.
Marieke Aarts,Hilde Dannenberg,Ronald J. deLeeuw,Francien H van Nederveen,Albert A.J. Verhofstad,Jacques W.M. Lenders,Winand N.M. Dinjens,Ernst-Jan M. Speel,Wan L. Lam,Ronald R. de Krijger +9 more
TL;DR: Data strongly suggest that chromosome arm 1p is the site for multiple tumor suppressor genes, although the potential candidate genes CDKN2C and PTPRF/LAR are not included in these regions.
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Genetic analyses of apparently sporadic pheochromocytomas: the Rotterdam experience.
Esther Korpershoek,F.H. van Nederveen,Hilde Dannenberg,Bart-Jeroen Petri,Paul Komminoth,Aurel Perren,Jacques W.M. Lenders,Albert A.J. Verhofstad,W. W. de Herder,R.R. de Krijger,Winand N.M. Dinjens +10 more
TL;DR: Although 7.5% germline mutations in a series of apparently sporadic PCCs are far less than the more than 20% reported in the literature, the figure is significant enough to consider germline mutation testing for each patient with PCC.
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