Hideto Obata
Osaka University
8 Papers
83 Citations
Hideto Obata is an academic researcher from Osaka University. The author has contributed to research in topics: Promoter & Gene. The author has an hindex of 6, co-authored 8 publications.
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Papers
Dominant‐negative STAT1 SH2 domain mutations in unrelated patients with mendelian susceptibility to mycobacterial disease
Miyuki Tsumura,Satoshi Okada,Satoshi Okada,Hidemasa Sakai,Shin'ichiro Yasunaga,Motoaki Ohtsubo,Takuji Murata,Hideto Obata,Takahiro Yasumi,Xiao-Fei Kong,Avinash Abhyankar,Toshio Heike,Tatsutoshi Nakahata,Ryuta Nishikomori,Saleh Al-Muhsen,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Jean-Laurent Casanova,Jean-Laurent Casanova,Mofareh AlZahrani,Mohammed A. Al Shehri,Geyhad ElGhazali,Yoshihiro Takihara,Masao Kobayashi +23 more
TL;DR: The first dominant mutations in the SH2 domain of STAT1 are described, revealing the importance of this domain for tyrosine phosphorylation and DNA binding, as well as for antimycobacterial immunity.
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Clinical outcome of patients with Ewing sarcoma family of tumors of bone in Japan: the Japanese Musculoskeletal Oncology Group cooperative study.
Hideto Obata,Takafumi Ueda,Akira Kawai,Takeshi Ishii,Toshifumi Ozaki,Satoshi Abe,Kazuhiro Tanaka,Hiroyuki Tsuchiya,Akihiko Matsumine,Hiroo Yabe +9 more
TL;DR: The objective of the current study was to assess the clinical outcome and prognostic factors of patients with ESFT of bone in Japan and to compare them between Euro‐American and Japanese populations.
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Smooth Muscle Cell Phenotype-dependent Transcriptional Regulation of the α1 Integrin Gene
Hideto Obata,Ken-ichiro Hayashi,Wataru Nishida,Takuya Momiyama,Atsumasa Uchida,Takahiro Ochi,Kenji Sobue +6 more
TL;DR: The results indicate that α1 integrin expression in smooth muscle cells is regulated transcriptionally in a phenotype-dependent manner and that serum response factor binding plays a crucial role in this regulation.
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Functional involvement of serum response factor in the transcriptional regulation of caldesmon gene
Takuya Momiyama,Ken-ichiro Hayashi,Hideto Obata,Yoshihiro Chimori,Toshirou Nishida,Toshinori Ito,Wataru Kamiike,Hikaru Matsuda,Kenji Sobue +8 more
TL;DR: Fractionation of smooth muscle cells' nuclear extracts using DNA affinity paramagnetic particles suggests that SRF transactivates the caldesmon promoter in concert with additional factors in the flow-through fraction recruited to the CArG element.
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Treatment outcomes of Japanese patients with Ewing sarcoma: differences between skeletal and extraskeletal Ewing sarcoma.
Satoshi Takenaka,Norifumi Naka,Hideto Obata,Susumu Joyama,Kenichiro Hamada,Yoshinori Imura,Shigeki Kakunaga,Yasuaki Aoki,Takafumi Ueda,Nobuhito Araki,Hideki Yoshikawa +10 more
TL;DR: The outcome of patients with Ewing sarcoma in Japan has improved in the last decade, and the outcomes and prognostic factors are similar for Japanese and Caucasian patients, though in this series of Japanese patients, a better prognosis was observed for patients with extraskeletal rather than skeletal Ewing Sarcoma.
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