Hideki Kobayashi
Howard Hughes Medical Institute
5 Papers
Hideki Kobayashi is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Stem cell & CD34. The author has an hindex of 5, co-authored 5 publications.
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Papers
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
Bi-Sen Ding,Daniel J. Nolan,Jason M. Butler,Daylon James,Alexander O. Babazadeh,Zev Rosenwaks,Vivek Mittal,Hideki Kobayashi,Koji Shido,David Lyden,Thomas N. Sato,Sina Y. Rabbany,Sina Y. Rabbany,Shahin Rafii +13 more
TL;DR: It is shown that inducible genetic ablation of vascular endothelial growth factor (VEGF)-A receptor-2 (VEGFR2) in the LSECs impairs the initial burst of hepatocyte proliferation and subsequent reconstitution of the hepatovascular mass by inhibiting upregulation of the endothelial-cell-specific transcription factor Id1, which suggests an instructive vascular niche in the early phases of physiological liver regeneration.
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Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells
Jason M. Butler,Daniel J. Nolan,Eva L. Vertes,Barbara Varnum-Finney,Hideki Kobayashi,Andrea T. Hooper,Marco Seandel,Marco Seandel,Koji Shido,Ian A. White,Mariko Kobayashi,Larry Witte,Chad May,Carrie J. Shawber,Yuki Kimura,Jan Kitajewski,Zev Rosenwaks,Irwin D. Bernstein,Shahin Rafii +18 more
TL;DR: Angiogenic models are developed to demonstrate that EC-derived angiocrine growth factors support in vitro self-renewal and in vivo repopulation of authentic LT-HSCs, and establish an instructive vascular niche for clinical-scale expansion of LT- HSCs and a cellular platform to identify stem cell-active trophogens.
693
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors
TL;DR: It is proposed that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens.
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene
Marco Seandel,Jason M. Butler,Hideki Kobayashi,Andrea T. Hooper,Ian A. White,Fan Zhang,Eva L. Vertes,Mariko Kobayashi,Yan Zhang,Sergey V. Shmelkov,Neil R. Hackett,Sina Y. Rabbany,Julie L. Boyer,Shahin Rafii +13 more
TL;DR: L Lentiviral introduction of E4ORF1 into human PECs increased the long-term survival of these cells in serum/cytokine-free conditions, while preserving their in vivo angiogenic potential for tubulogenesis and sprouting, and established an Akt-dependent durable vascular niche.
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
Hideki Kobayashi,Jason M. Butler,Rebekah K. O'Donnell,Mariko Kobayashi,Bi-Sen Ding,Bryant Bonner,Vi K. Chiu,Daniel J. Nolan,Koji Shido,Laura E. Benjamin,Shahin Rafii,Shahin Rafii +11 more
TL;DR: It is demonstrated that Akt activation in endothelial cells, through recruitment of mTOR, but not the FoxO pathway, upregulates specific angiocrine factors that support expansion of CD34−Flt3− KLS HSPCs with long-term haematopoietic stem cell (LT-HSC) repopulation capacity.