Hideki Hasegawa
National Institutes of Health
230 Papers
1.2K Citations
Hideki Hasegawa is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Vaccination. The author has an hindex of 47, co-authored 230 publications. Previous affiliations of Hideki Hasegawa include University College Dublin & Global Virus Network.
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Papers
Analysis of bronchoalveolar lavage fluid in a mouse model of bronchial asthma and H1N1 2009 infection.
Seigo Okada,Shunji Hasegawa,Hideki Hasegawa,Akira Ainai,Ryo Atsuta,Kenzo Ikemoto,Kohsuke Sasaki,Shoichi Toda,Komei Shirabe,Midori Takahara,Sawako Harada,Tsuneo Morishima,Takashi Ichiyama +12 more
TL;DR: Severe pulmonary inflammation induced by elevated levels of cytokines, combined with increased viral replication due to decreased IFN-γ levels, may contribute to worsening respiratory symptoms in patients with bronchial asthma and A(H1N1)pdm09 infection.
Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I
Hideki Hasegawa,Hirofumi Sawa,Martha J. Lewis,Martha J. Lewis,Yasuko Orba,Noreen Sheehy,Yoshie Yamamoto,Takeshi Ichinohe,Yasuko Tsunetsugu-Yokota,Harutaka Katano,Hidehiro Takahashi,Junichiro Matsuda,Tetsutaro Sata,Takeshi Kurata,Kazuo Nagashima,William W. Hall +15 more
TL;DR: The generation of HTLV-I Tax transgenic mice is described using the Lck proximal promoter to restrict transgene expression to developing thymocytes and this model accurately reproduces human disease and will provide a tool for analysis of the molecular events in transformation and for the development of new therapeutics.
Host Adaptation and the Alteration of Viral Properties of the First Influenza A/H1N1pdm09 Virus Isolated in Japan
Akira Ainai,Hideki Hasegawa,Masatsugu Obuchi,Takato Odagiri,Makoto Ujike,Makoto Ujike,Masayuki Shirakura,Eri Nobusawa,Masato Tashiro,Hideki Asanuma +9 more
TL;DR: Extended passaging allowed influenza A/N to adapt to different hosts, as indicated by a high increase in proliferative capacity that was accompanied by an antigenic alteration leading to amino acid substitutions.
Impacts of allergic airway inflammation on lung pathology in a mouse model of influenza A virus infection.
Akira Kawaguchi,Tadaki Suzuki,Yuki Ohara,Kenta Takahashi,Yuko Sato,Akira Ainai,Noriyo Nagata,Masato Tashiro,Hideki Hasegawa +8 more
TL;DR: A murine model of influenza virus/asthma comorbidity using NC/Nga mice, which are highly sensitive to allergic reactions such as atopic dermatitis and allergic airway inflammation, was developed and showed that induction of acute allergicAirway inflammation in pre-existing influenza virus infection had additive effects on exacerbation of lung pathology, which mirrors findings in human epidemiological studies.
Effects of Toll-like Receptor Stimulation on Eosinophilic Infiltration in Lungs of BALB/c Mice Immunized with UV-inactivated Severe Acute Respiratory Syndrome-related Coronavirus Vaccine
Naoko Iwata-Yoshikawa,Akihiko Uda,Tadaki Suzuki,Yasuko Tsunetsugu-Yokota,Yuko Sato,Shigeru Morikawa,Masato Tashiro,Tetsutaro Sata,Hideki Hasegawa,Noriyo Nagata +9 more
TL;DR: It is found that TLR stimulation reduced the high level of eosinophilic infiltration that occurred in the lungs of mice immunized with UV-inactivated SARS-CoV, suggesting that vaccine-induced eos inophil immunopathology in the Lungs upon SARS -CoV infection could be avoided by the TLR agonist adjuvants.