Hideki Hasegawa
National Institutes of Health
230 Papers
1.2K Citations
Hideki Hasegawa is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Vaccination. The author has an hindex of 47, co-authored 230 publications. Previous affiliations of Hideki Hasegawa include University College Dublin & Global Virus Network.
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Papers
Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation
Noriyo Nagata,Takuya Iwasaki,Takuya Iwasaki,Yasushi Ami,Yoshio Tano,Ayako Harashima,Yuriko Suzaki,Yuko Sato,Hideki Hasegawa,Tetsutaro Sata,Tatsuo Miyamura,Hiroyuki Shimizu +11 more
TL;DR: An improved simian model of EV71 infection was established by using intravenous inoculation, which revealed clinical and neuropathological similarities between this model and human cases of encephalitis and correlated well with the apparent differences in neurological disease induced by EV71 and PV1-OM1.
Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia
Hiba El Hajj,Marwan El-Sabban,Hideki Hasegawa,Hideki Hasegawa,Ghazi Zaatari,Julien Ablain,Shahrazad Saab,Anne Janin,Rami Mahfouz,Rihab Nasr,Youmna Kfoury,Christophe Nicot,Olivier Hermine,William W. Hall,Ali Bazarbachi +14 more
TL;DR: Treatment with a combination of interferon-α and arsenic trioxide ablates leukemia-initiating activity before reducing primary tumor bulk in a murine model of adult T cell leukemia.
Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus
Masayuki Saijo,Shigeru Morikawa,Shuetsu Fukushi,Tetsuya Mizutani,Hideki Hasegawa,Noriyo Nagata,Naoko Iwata,Ichiro Kurane +7 more
TL;DR: The activity of inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitors, mizoribine and ribavirin, against severe acute respiratory syndrome (Sars)-associated coronavirus (SARS-CoV) was determined by plaque reduction and yield reduction assays.
Deep-sequence identification and role in virus replication of a JC virus quasispecies in patients with progressive multifocal leukoencephalopathy
Kenta Takahashi,Tsuyoshi Sekizuka,Hitomi Fukumoto,Kazuo Nakamichi,Tadaki Suzuki,Yuko Sato,Hideki Hasegawa,Makoto Kuroda,Harutaka Katano +8 more
TL;DR: In vitro studies showed that the mutation strongly repressed the expression of JC viral proteins and reduced the viral replication, and JC virus replicates in PML lesions in the presence of a mutant virus which is able to repress virus replication.
Evidence for human herpesvirus-6B infection of regulatory T-cells in acute systemic lymphadenitis in an immunocompetent adult with the drug reaction with eosinophilia and systemic symptoms syndrome: A case report
Sohtaro Mine,Sohtaro Mine,Koyu Suzuki,Yuko Sato,Hitomi Fukumoto,Michiyo Kataoka,Naoki Inoue,Chiho Ohbayashi,Hideki Hasegawa,Tetsutaro Sata,Masashi Fukayama,Harutaka Katano +11 more
TL;DR: This case provides direct evidence of HHV-6 infection in CD25(+)/FoxP3(+) T cells in a case of acute lymphadenitis of DRESS syndrome, suggesting a significant role of HHVs infection of regulatory T-cells in the pathogenesis of DRress syndrome.