Hideharu Ishida
Gifu University
5 Papers
17 Citations
Hideharu Ishida is an academic researcher from Gifu University. The author has contributed to research in topics: Ligand (biochemistry) & Neuraminidase. The author has an hindex of 4, co-authored 5 publications.
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Papers
A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1–N9 Neuraminidases: Insight into Neuraminidase–Inhibitor Interactions
Nongluk Sriwilaijaroen,Nongluk Sriwilaijaroen,Sadagopan Magesh,Akihiro Imamura,Hiromune Ando,Hideharu Ishida,Miho Sakai,Erika Ishitsubo,Takanori Hori,Setsuko Moriya,Takeshi Ishikawa,Kazuo Kuwata,Takato Odagiri,Masato Tashiro,Hiroaki Hiramatsu,Kenji Tsukamoto,Taeko Miyagi,Hiroaki Tokiwa,Makoto Kiso,Yasuo Suzuki +19 more
TL;DR: Broad efficacy of cPro-GUN against avian and human influenza viruses in cell cultures comparable to its sialidase inhibitory activities makes cPro -GUN ideal for further development for safe therapeutic or prophylactic use against both seasonal and pandemic influenza.
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Six independent fucose-binding sites in the crystal structure of Aspergillus oryzae lectin.
Hisayoshi Makyio,Junpei Shimabukuro,Tatsuya Suzuki,Tatsuya Suzuki,Akihiro Imamura,Hideharu Ishida,Makoto Kiso,Makoto Kiso,Hiromune Ando,Hiromune Ando,Ryuichi Kato +10 more
TL;DR: The crystal structure of AOL (a fucose-specific lectin of Aspergillus oryzae) has been solved by SAD and MAD (multi-wavelength anomalous diffraction) phasing of seleno-fucosides.
18
Synthesis of seleno-fucose compounds and their application to the X-ray structural determination of carbohydrate-lectin complexes using single/multi-wavelength anomalous dispersion phasing.
Junpei Shimabukuro,Hisayoshi Makyio,Tatsuya Suzuki,Tatsuya Suzuki,Yosuke Nishikawa,Masato Kawasaki,Akihiro Imamura,Hideharu Ishida,Hiromune Ando,Hiromune Ando,Ryuichi Kato,Makoto Kiso,Makoto Kiso +12 more
TL;DR: Selenium-incorporated fucoses (seleno-fucoses) differing in the position of the seleno-substituent were synthesized and applied to the X-ray structural determination of a carbohydrate-lectin complex using single/multi-wavelength anomalous dispersion (SAD/MAD) phasing.
16
Efficient Synthesis of the Lewis A Tandem Repeat.
Daisuke Kobayashi,Akiharu Ueki,Akiharu Ueki,Akiharu Ueki,Tomoya Yamaji,Kazuya Nagao,Akihiro Imamura,Hiromune Ando,Hiromune Ando,Makoto Kiso,Makoto Kiso,Hideharu Ishida +11 more
TL;DR: The convergent synthesis of the Lewis A (Lea) tandem repeat is described, a carbohydrate ligand for a mannose binding protein that shows potent inhibitory activity against carcinoma growth.
Raft-based interactions of gangliosides with a GPI-anchored receptor
Naoko Komura,Naoko Komura,Kenichi G. N. Suzuki,Kenichi G. N. Suzuki,Hiromune Ando,Hiromune Ando,Miku Konishi,Miku Konishi,Machi Koikeda,Akihiro Imamura,Rahul Chadda,Takahiro K. Fujiwara,Hisae Tsuboi,Ren Sheng,Wonhwa Cho,Koichi Furukawa,Keiko Furukawa,Yoshio Yamauchi,Hideharu Ishida,Akihiro Kusumi,Akihiro Kusumi,Makoto Kiso,Makoto Kiso +22 more
TL;DR: Methods for systematically synthesizing analogs that behave like their native counterparts in regard to partitioning into raft-related membrane domains or preparations show that gangliosides continually and dynamically exchange between raft domains and the bulk domain, indicating that raft domains are dynamic entities.