Hideharu Ishida
Gifu University
5 Papers
25 Citations
Hideharu Ishida is an academic researcher from Gifu University. The author has contributed to research in topics: Binding site & Crystal structure. The author has an hindex of 5, co-authored 5 publications.
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Papers
The Crystal Structure of Tetanus Toxin Hc Fragment Complexed with a Synthetic GT1b Analogue Suggests Cross-linking between Ganglioside Receptors and the Toxin
Constantina Fotinou,Paul Emsley,Isobel Black,Hiromune Ando,Hideharu Ishida,Makoto Kiso,Katharine Sinha,Neil F. Fairweather,Neil W. Isaacs +8 more
TL;DR: The crystal structure of the complex of the COOH-terminal fragment of the heavy chain with an analogue of its ganglioside receptor, GT1b, provides the first direct identification and characterization of the gangliosiside-binding sites.
184
Characterization of High-Affinity Binding between Gangliosides and Amyloid β-Protein
TL;DR: The results seem to indicate that an alpha2,3NeuAc residue on the neutral oligosaccharide core is required for binding of amyloid beta-protein, and the alpha2-6Neuac residue linked to GalNAc contributes significantly to binding affinity for A beta.
156
6-O-sulfo de-N-acetylsialyl Lewis X as a novel high-affinity ligand for human L-selectin: total synthesis and structural characterization.
TL;DR: The structure of 6-Osulfo deNacetylsialyl Lewis X ganglioside was characterized by fast atom bombardment mass spectrometry (FABMS) and achieved by a highly efficient, regio and α stereoselective glycosylation of Ntrifluoroacetylneuraminic acid.
17
The first synthesis of glycan parts of lactoganglio- and neolactoganglio-series gangliosides
TL;DR: The glycan parts of the neolactoganglio-series of gangliosides were synthesized for the first time based on a well-designed synthetic strategy as mentioned in this paper.
8
The aglycone of sulfogalactolipids can alter the sulfate ester substitution position required for hsc70 recognition
Daniel Mamelak,Murugesapillai Mylvaganam,Eiji Tanahashi,Hiromi Ito,Hideharu Ishida,Makoto Kiso,Clifford A. Lingwood +6 more
TL;DR: These studies demonstrate the highly specific nature of hsc70/SGL binding and show, for the first time, that the lipid aglycone can alter the substitution position requirement for glycolipid recognition.