Hideaki Amada
Taisho Pharmaceutical Co.
42 Papers
201 Citations
Hideaki Amada is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Alkyl & Alkoxy group. The author has an hindex of 8, co-authored 42 publications.
Chat about Author
Papers
Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors
Toshio Nakamura,Hiroyuki Kakinuma,Hiroki Umemiya,Hideaki Amada,Noriyuki Miyata,Kazuo Taniguchi,Kagumi Bando,Masakazu Sato +7 more
TL;DR: Some derivatives of imidazole 1 which had an amino group on the side chain showed potent and selective inhibitory activity, and found that a dimethylaminohexyloxy derivative showed potency and selectivity for cytochrome P450s.
76
Patent
C-phenyl glycitol compound for the treatment of diabetes
Hideaki Amada,Yuko Hashimoto,Yuki Iwata,Hiroyuki Kakinuma,Yohei Kobashi,Takahiro Oi,Hitomi Takahashi +6 more
- 18 May 2007
TL;DR: In this paper, a novel C-phenyl glycitol compound that may serve as a prophylactic or therapeutic agent for diabetes by inhibiting both SGLT1 activity and SGLt2 activity, thereby exhibiting a glucose absorption suppression action and a urine glucose excretion action.
53
Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
Fumihito Ushiyama,Hideaki Amada,Takeuchi Tomoki,Nozomi Tanaka-Yamamoto,Harumi Kanazawa,Koichiro Nakano,Masashi Mima,Aiko Masuko,Iichiro Takata,Kosuke Hitaka,Kunihiko Iwamoto,Hiroyuki Sugiyama,Norikazu Ohtake +12 more
- 24 Apr 2020
TL;DR: Hit-to-lead (H2L) chemistry is applied for the identification of a new chemical class of GyrB/ParE inhibitors by efficient use of thermodynamic parameters and advanced into further optimization for creating novel antibacterial agents.
50
Imidazole Derivatives as New Potent and Selective 20-HETE Synthase Inhibitors.
Toshio Nakamura,Hiroyuki Kakinuma,Hiroki Umemiya,Hideaki Amada,Noriyuki Miyata,Kazuo Taniguchi,Kagumi Bando,Masakazu Sato +7 more
TL;DR: In this article, the authors examined some derivatives of imidazole 1 which had an amino group on the side chain, and found that a dimethylaminohexyloxy derivative (3g; IC(50) value of 8.8 nM) showed potent and selective inhibitory activity.
46
Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.
Masakazu Sato,Takaaki Ishii,Yuko Kobayashi-Matsunaga,Hideaki Amada,Kazuo Taniguchi,Noriyuki Miyata,Kazuya Kameo +6 more
TL;DR: An examination of the structure-activity relationship revealed that the unsubstituted hydroxyformamidine moiety and the substituent at the para-position of the N-hydroxyformamazine moiety are necessary for the potent activity of HET0016.
45