HG Drexler
Leibniz Institute for Neurobiology
20 Papers
186 Citations
HG Drexler is an academic researcher from Leibniz Institute for Neurobiology. The author has contributed to research in topics: Gene & Lymphoma. The author has an hindex of 9, co-authored 20 publications.
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Papers
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control
Helene Kretzmer,Stephan H. Bernhart,Wei Wang,Andrea Haake,Marc A. Weniger,Anke K. Bergmann,Matthew J. Betts,Enrique Carrillo-de-Santa-Pau,Gero Doose,Jana Gutwein,Julia Richter,Volker Hovestadt,Bingding Huang,Daniel Rico,Frank Jühling,Julia Kolarova,Qianhao Lu,Christian Otto,Rabea Wagener,Judith Arnolds,Birgit Burkhardt,Alexander Claviez,HG Drexler,Sonja Eberth,Sonja Eberth,Roland Eils,Roland Eils,Paul Flicek,Siegfried Haas,Michael Hummel,Dennis Karsch,Hinrik H.D. Kerstens,Wolfram Klapper,Markus Kreuz,Chris Lawerenz,Dido Lenze,Markus Loeffler,Cristina López,Roderick A. F. MacLeod,Joost H.A. Martens,Marta Kulis,José I. Martín-Subero,Peter Möller,Inga Nagel,Simone Picelli,Inga Vater,Marius Rohde,Philip Rosenstiel,Maciej Rosolowski,Robert B. Russell,Markus Schilhabel,Matthias Schlesner,Peter F. Stadler,Monika Szczepanowski,Lorenz Trümper,Hendrik G. Stunnenberg,Ralf Küppers,Ole Ammerpohl,Peter Lichter,Reiner Siebert,Steve Hoffmann,Bernhard Radlwimmer +61 more
TL;DR: The results demonstrate a tight connection between somatic mutation, DNA methylation and transcriptional control in key B cell pathways deregulated differentially in Burkitt lymphoma and other germinal center B cell lymphomas.
•Journal Article
Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines.
G. Meierhoff,Dehmel U,H. J. Gruss,Olivier Rosnet,Daniel Birnbaum,Hilmar Quentmeier,W. G. Dirks,HG Drexler +7 more
TL;DR: The FLT3 gene encodes a receptor tyrosine kinase that is closely related to two well-known receptors, KIT and FMS, that regulate with their respective ligands, stem cell factor (SCF) and macrophage colony-stimulating factor (M-CSF), proliferation and differentiation of hematopoietic cells.
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•Journal Article
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3.
TL;DR: Two new leukemia cell lines with myeloid or monocytic features which are growth factor-responsive, one of them carrying a unique chromosomal translocation will be of particular value for investigating the complex cytokine network and molecular events caused by chromosomal aberrations.
98
MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines
TL;DR: Three genes regulated by NKX2-5 in T-ALL cells are identified, including myocyte enhancer factor 2C (MEF2C), which consistently inhibits expression of NR4A1/NUR77, which regulates apoptosis via BCL2 transformation.
64
•Journal Article
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
TL;DR: Analysis of 50 continuous human cell lines established from various types of non-Hodgkin's lymphoma, ALCL and HD shows that the notion that the t(2;5) represents a chromosomal aberration common to both AL CL and HD is not supported.
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