Hewei Dong
7 Papers
Hewei Dong is an academic researcher. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 3, co-authored 6 publications.
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Papers
Selenium as an emerging versatile player in heterocycles and natural products modification.
TL;DR: In this paper , different organoselenium species affect cellular oxidative stress levels, and try to correlate the structural properties of selenium-containing heterocycles and natural product derivatives to their biological activities and therapeutic applications.
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Metal‐Free and Open‐Air Arylation Reactions of Diaryliodonium Salts for DNA‐Encoded Library Synthesis (Adv. Sci. 26/2022)
Hongtao Xu,Tingting Tan,Yi-Ying Zhang,Yan Wang,Kangyin Pan,Ying Yao,Shuning Zhang,Yuang Gu,Wanting Chen,Jie Li,Hewei Dong,Yu Meng,Peixiang Ma,Wei Hou,Guangsheng Yang +14 more
TL;DR: Xu et al. as discussed by the authors developed the first on-DNA meeting diaryliodonium salts (DAI) chemistry and realized the selective arylation of phenols and oximes with both high yield and DNA fidelity via substrate activation strategy.
Design, synthesis and an anti-proliferative activity study of C-14 amide substituted derivatives of dehydroabietic acid
TL;DR: In this article , a series of new C-14 amide substituted derivatives of dehydroabietic acid were designed, synthesized and evaluated for their anti-proliferative activity.
Bioinspired Selenium-Nitrogen Exchange (SeNEx) Click Chemistry Suitable for Nanomole-Scale Medicinal Chemistry and Bioconjugation.
Wei Hou,Yi-Ying Zhang,Fuchao Huang,Wanting Chen,Yuang Gu,Yan Wang,Jiacheng Pang,Hewei Dong,Kangyin Pan,Shuning Zhang,Peixiang Ma,Hongtao Xu +11 more
- 11 Feb 2024
TL;DR: The first Selenium-Nitrogen Exchange (SeNEx) click chemistry between benzoselenazolones and terminal alkynes is reported, which is inspired by the biochemical SeNEx between Ebselen and cysteine (Cys) residue and formed selenoalkyne connection is readily elaborated, thus endowing this chemistry with multidimensional molecular diversity.
A Selenylation Chemistry Suitable for On-Plate Parallel and On-DNA Library Synthesis Enabling High-Throughput Medicinal Chemistry.
Hongtao Xu,Yan Wang,Hewei Dong,Yi-Ying Zhang,Yuang Gu,Shuning Zhang,Yu Meng,Jie Li,Xiaohong Shi,Qun Ji,Lili Liu,Peixiang Ma,Fei Ma,Guang Yang,Wei Hou +14 more
TL;DR: Using this method, a library of 1350 indole-selenides was parallel synthesized in an efficient and practical manner, enabling the rapid identification of 3ai as a promising compound with nanomolar antiproliferative activity in cancer cells via in situ phenotypic screening.