Hester Happé
Leiden University Medical Center
11 Papers
96 Citations
Hester Happé is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Autosomal dominant polycystic kidney disease & Polycystic kidney disease. The author has an hindex of 8, co-authored 11 publications.
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Papers
Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways
Hester Happé,Wouter N. Leonhard,Annemieke van der Wal,Bob van de Water,Irma S. Lantinga-van Leeuwen,Martijn H. Breuning,Emile de Heer,Dorien J.M. Peters +7 more
TL;DR: It is proposed that during tissue repair, the integrity of the newly formed Pkd1-deficient cells is modified rendering them susceptible to subsequent cyst formation, and Aberrant planar cell polarity (PCP) signaling and increased canonical Wnt signaling are suggested to be involved in Cyst formation.
Altered Hippo signalling in polycystic kidney disease.
Hester Happé,Annemieke van der Wal,Wouter N. Leonhard,Steven J. Kunnen,Martijn H. Breuning,Emile de Heer,Dorien J.M. Peters +6 more
TL;DR: Altered activity of the Hippo pathway was confirmed in renal tissues from human ADPKD and ARPKD patients, as well as in cystic renal tumours, strengthening the concept that during epithelial repair Four‐jointed is involved in PCP signalling, while in cysts kidneys it is related to Hippo signalling and cyst growth.
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Translational research in ADPKD: lessons from animal models
Hester Happé,Dorien J.M. Peters +1 more
TL;DR: An update on the preclinical models commonly used to study the molecular pathogenesis of ADPKD and test potential therapeutic strategies is provided and progress made in understanding the pathophysiology of human AD PKD through these animal models is discussed.
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Polycystic kidney disease: The complexity of planar cell polarity and signaling during tissue regeneration and cyst formation☆
TL;DR: The involvement of different signaling pathways during renal development, renal epithelial regeneration and cyst formation in ADPKD is reviewed, focusing on planar cell polarity (PCP) and oriented cell division (OCD).
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Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease
Edwin M. Spithoven,Maatje D.A. van Gastel,A. Lianne Messchendorp,Niek F. Casteleijn,Joost P. H. Drenth,Carlo A. J. M. Gaillard,Johan W. de Fijter,Esther Meijer,Dorien J.M. Peters,Peter Kappert,Remco J. Renken,Folkert W. Visser,Jack F.M. Wetzels,Robert Zietse,Ron T. Gansevoort,Hedwig M. A. D'Agnolo,H. Dekker,Joost P.H. Drenth,Tom J. G. Gevers,Hester Happé,Gert J. Ter Horst,Remco K Renken,H. Pieterman,Mahdi Salih,Darius Soonawala,Vicente E. Torres,Martin N. J. M. Wasser,Marjolein van Buren,Nick Veeger,Marc G. Vervloet +29 more
TL;DR: ETKVellipsoid requires less time than eTKVPANK and can detect change in TKV over time and is suggested that this method may be preferable in clinical care.
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