Hesham E Basma
University of Tennessee Health Science Center
5 Papers
198 Citations
Hesham E Basma is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Superantigen & Streptococcus. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Hesham E Basma include Veterans Health Administration.
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Papers
Genetic relatedness and superantigen expression in group A streptococcus serotype M1 isolates from patients with severe and nonsevere invasive diseases.
Sonia Chatellier,Nahla Ihendyane,Rita Kansal,Rita Kansal,Farukh Khambaty,Hesham E Basma,Hesham E Basma,Anna Norrby-Teglund,Donald E. Low,Allison McGeer,Malak Kotb,Malak Kotb +11 more
TL;DR: The data indicate that highly related invasive M1T1 isolates, some indistinguishable, can cause disease of varying severity in different individuals, and underscore the contribution of host factors to the outcome of invasive GAS infections.
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Risk Factors in the Pathogenesis of Invasive Group A Streptococcal Infections: Role of Protective Humoral Immunity
Hesham E Basma,Hesham E Basma,Anna Norrby-Teglund,Yajaira B Guedez,Allison McGeer,Donald E. Low,Omar El-Ahmedy,Benjamin Schwartz,Malak Kotb,Malak Kotb +9 more
TL;DR: Studying 33 patients with invasive infection caused by genotypically indistinguishable M1T1 strains of Streptococcus pyogenes suggests that low levels of protective antibodies may contribute to host susceptibility to invasive streptococcal infection but do not modulate disease outcome.
139
Varying Titers of Neutralizing Antibodies to Streptococcal Superantigens in Different Preparations of Normal Polyspecific Immunoglobulin G: Implications for Therapeutic Efficacy
TL;DR: The study suggests that complete neutralizing activity may be achieved by optimizing the type and/or dose of IVIG used in treatment, and this variation paralleled differences in the neutralizing titer of the IVIG lot administered to each patient studied.
104
Relative Neutralizing Activity in Polyspecific IgM, IgA, and IgG Preparations against Group A Streptococcal Superantigens
Anna Norrby-Teglund,Nahla Ihendyane,Rita Kansal,Rita Kansal,Hesham E Basma,Hesham E Basma,Malak Kotb,Malak Kotb,Jan Andersson,Lennart Hammarström +9 more
TL;DR: The data show that IgM and IgA are potent inhibitors of specific streptococcal superantigens, which may have implications for the optimization of immunotherapy in invasive strePTococcal infections.
72
Opsonic Antibodies to the Surface M Protein of Group A Streptococci in Pooled Normal Immunoglobulins (IVIG): Potential Impact on the Clinical Efficacy of IVIG Therapy for Severe Invasive Group A Streptococcal Infections
Hesham E Basma,Hesham E Basma,Anna Norrby-Teglund,Allison McGeer,Donald E. Low,Omar El-Ahmedy,Omar El-Ahmedy,James B. Dale,Benjamin Schwartz,Malak Kotb,Malak Kotb +10 more
TL;DR: The results reveal another potential mechanism by which IVIG can ameliorate severe invasive group A streptococcal infections and reveal a good correlation between ELISA titers and opsonophagocytic activity.
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