Herbert Y. Gaisano
University of Toronto
229 Papers
3.2K Citations
Herbert Y. Gaisano is an academic researcher from University of Toronto. The author has contributed to research in topics: Exocytosis & Insulin. The author has an hindex of 50, co-authored 216 publications. Previous affiliations of Herbert Y. Gaisano include Ontario Institute for Cancer Research & Mayo Clinic.
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Papers
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
Nadeeja Wijesekara,Feihan F. Dai,Alexandre B. Hardy,P. R. Giglou,Alpana Bhattacharjee,Vasilij Koshkin,Fabrice Chimienti,Herbert Y. Gaisano,Guy A. Rutter,Michael B. Wheeler +9 more
TL;DR: The data indicate that while, under the conditions studied, ZnT8 is absolutely essential for proper beta cell function, it is largely dispensable for alpha cell function.
Impaired Gene and Protein Expression of Exocytotic Soluble N-Ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients
TL;DR: The view that decreased islet RNA and protein expression of SNARE and SNARE-modulating proteins plays a role in impaired insulin secretion in type 2 diabetic patients remains unclear, however, to which extent this defect is primary or secondary to, e.g., glucotoxicity.
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Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells.
TL;DR: Syntaxins are cytoplasmically oriented integral membrane soluble NEM-sensitive factor receptors (SNAREs) thought to serve as targets for t... as mentioned in this paper, i.e.
Distinct Cellular Locations oftheSyntaxin Family of Proteins inRatPancreatic AcinarCells
Herbert Y. Gaisano,Antony Bouquillon +1 more
- 01 Jan 1996
TL;DR: It is shown that in the exocrine acinar cell of the pancreas, multiple syntaxin isoforms are expressed and that they appear to reside in distinct membrane compartments, and that these proteins are capable of specific interaction with vesicle SNARE proteins.
180
Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis
Fuzhen Xia,Xiaodong Gao,Edwin P. Kwan,Patrick P.L. Lam,Lillian Chan,Keiyan Sy,Laura Sheu,Michael B. Wheeler,Herbert Y. Gaisano,Robert G. Tsushima +9 more
TL;DR: Membrane compartmentalization of ion channels and SNARE proteins in lipid rafts may be critical for the temporal and spatial coordination of insulin release, forming what has been described as the excitosome complex.
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