This invention relates to compounds of the formula I or an optical isomer thereof wherein R1 and R2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R3, R4 and R5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R3, R4, and R5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.

N[ omega ,( omega -1)-dialkyloxy]- and N-[ omega ,( omega -1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor

Compositions, systems and methods that allow for the detection of the actual physical delivery of a pharmaceutical agent to a body are provided. Embodiments of the compositions include an identifier and an active agent. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.

Pharma-informatics system

A Negishi cross-coupling of alkylpyridinium salts and alkylzinc halides has been developed. This is the first example of alkyl–alkyl bond formation via cross-coupling of an alkyl amine derivative w...

/pdf/harnessing-alkylpyridinium-salts-as-electrophiles-in-12hiu93u67.pdf

Harnessing Alkylpyridinium Salts as Electrophiles in Deaminative Alkyl–Alkyl Cross-Couplings

The invention relates to compounds of formula (I) wherein R1 is aryl or heteroaryl, wherein the aryl and heteroaryl groups may be unsubstituted or substituted by one to three substituents, selected from the group consisting of cycloalkyl, phenyl, phenyloxy, benzyl, benzyloxy, halogen, lower alkyl, lower alkoxy, heteroaryl, piperidin-1-yl or by lower alkyl substituted by halogen, or is aryl or heteroaryl wherein at least one hydrogen atom is replaced by deuterium or tritium; R2 is hydrogen, lower alkyl or is benzyl unsubstituted or substituted by alkoxy or halogen; or R1 and R2 form together with the N-atom to which they are attached 2,3-dihydroindol-1-yl or 3,4-dihydro-quinolin-1-yl; R3 is hydrogen or lower alkyl or to a pharmaceutically suitable acid addition salt thereof for the treatment of CNS disorders.

2-Aminooxazolines as TAAR1 ligands

The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5­HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.

Method of treating lower urinary tract disorders

Novel 1-phenoxy-2-hydroxy-3-isopropylamino-propane and acid addition salts thereof having bradycardia activity and N-isopropyl-nor-adrenaline activity and their preparation.

Novel 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes

Compounds of the formula ##STR1## wherein R 1 is halogen, hydroxyl, amino, alkyl, alkoxy or acylamido, R 2 is hydrogen, hydroxyl, alkyl, alkoxy or carboxamido, R 3 is hydrogen, halogen, alkyl or alkoxy, R 4 is hydrogen, methyl or ethyl, and R 5 and R 6 are each hydrogen, halogen, alkyl, alkoxy, benzyloxy, hydroxyl, amino, cyano, carboxyl, carbalkoxy, carboxamido, alkylenecarboxamido or acylamido, Provided, however, that, when R 1 is 4-hydroxyl or 4-chloro, R 2 and R 3 are hydrogen, R 4 is methyl and R 5 is halogen or 2-halo, R 6 is other than 4-hydroxyl or 4-benzyloxy; and nontoxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, vasodilators, hypotensives and antiarrhythmics.

N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines

The compounds are 1-phenoxy-2-hydroxy-3-alkylamino-propanes and non-toxic acid addition salts thereof, useful as beta -adrenolytics and hypotensives in warm-blooded animals.

1-phenoxy-2-hydroxy-3-sec. alkylamino-propanes

Anorexigenic compositions comprising a 1-phenyl-2-(lower alkylamino)-lower alkanone-(1) or a nontoxic acid addition salt thereof aS an active ingredient, and a method of curbing the appetite of warmblooded animals therewith.

Anorexigenic composition and method

Compounds of the formula ##EQU1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms, and R 1 is hydrogen or methyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anticonvulsives and antiarrhythmics in warmblooded animals.

1-(2',6'-Dimethyl-phenoxy)-2-amino-alkanes and salts thereof

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